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Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

European journal of medicinal chemistry, 2016-11, Vol.124, p.36-48

2016

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Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.205-207

2007

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Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6290-6294

2007

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.57-62

2007

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Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.511-516

2007

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12876-12882

2004

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Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes

Biochemistry (Easton), 2011-06, Vol.50 (22), p.4973-4980

2011

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discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.466-471

2013

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Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N 2 -[(2 S )-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]- N 1 -[(7 S )-5-methyl-6-oxo-6,7-dihydro-5 H -dibenzo[ b , d ]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1133-1143

2006

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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1592-1596

2015

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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Iminoheterocycles as γ-secretase modulators

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5380-5384

2010

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Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6032-6037

2009

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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.3143-3160

2002

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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.892-896

2012

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Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5330-5335

2007

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Iminoheterocycles as g-secretase modulators

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5380-5384

2010

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Novel orally active morpholine N-arylsulfonamides y-secretase inhibitors with low CYP 3A4 liability

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (21), p.6032-6037

2009

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Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1133

2006

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Chronic Treatment with the Î³-Secretase Inhibitor LY-411,575 Inhibits Î²-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12876

2004

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ChemInform Abstract: Insecticidal N-Arylalkyl-4-benzhydrolpiperidines: Optimization of the Benzhydrol Region

ChemInform, 2002-05, Vol.33 (20), p.no-no

2002

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Dehydrated human amniotic membrane modulates canonical Wnt signaling in multiple cell types in vitro

European journal of cell biology, 2021-06, Vol.100 (5-6), p.151168-151168, Article 151168

2021

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Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease

Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N 2 -[(2 S )-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]- N 1 -[(7 S )-5-methyl-6-oxo-6,7-dihydro-5 H -dibenzo[ b , d ]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse

Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Iminoheterocycles as γ-secretase modulators

Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors

Iminoheterocycles as g-secretase modulators

Novel orally active morpholine N-arylsulfonamides y-secretase inhibitors with low CYP 3A4 liability

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

Chronic Treatment with the Î³-Secretase Inhibitor LY-411,575 Inhibits Î²-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

ChemInform Abstract: Insecticidal N-Arylalkyl-4-benzhydrolpiperidines: Optimization of the Benzhydrol Region

Dehydrated human amniotic membrane modulates canonical Wnt signaling in multiple cell types in vitro

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