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Lysosome: The metabolic signaling hub

Traffic (Copenhagen, Denmark), 2019-01, Vol.20 (1), p.27-38

2019

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Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

eLife, 2018-11, Vol.7

2018

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Cell, 2010-04, Vol.141 (2), p.290-303

2010

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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Science (American Association for the Advancement of Science), 2015-01, Vol.347 (6218), p.188-194

2015

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Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Science (American Association for the Advancement of Science), 2008-06, Vol.320 (5882), p.1496-1501

2008

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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

Cell reports (Cambridge), 2014-10, Vol.9 (1), p.1-8

2014

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C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

FEBS open bio, 2019-09, Vol.9 (9), p.1589-1602

2019

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Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

Nature chemical biology, 2019-05, Vol.15 (5), p.453

2019

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ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

Biochemistry (Easton), 2020-05, Vol.59 (19), p.1793-1799

2020

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Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

Cell reports (Cambridge), 2015-09, Vol.12 (9), p.1445-1455

2015

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Identification of Galacturonic Acid-1-phosphate Kinase, a New Member of the GHMP Kinase Superfamily in Plants, and Comparison with Galactose-1-phosphate Kinase

The Journal of biological chemistry, 2009-08, Vol.284 (32), p.21526-21535

2009

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Regulation of mTORC1 by amino acids

Trends in cell biology, 2014-07, Vol.24 (7), p.400-406

2014

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Chemical proteomics to study metabolism, a reductionist approach applied at the systems level

Cell chemical biology, 2024-03, Vol.31 (3), p.446-451

2024

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Principles and functions of metabolic compartmentalization

Nature metabolism, 2022-10, Vol.4 (10), p.1232

2022

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How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing

Cell chemical biology, 2019-09, Vol.26 (9), p.1195-1196

2019

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H⁺-ATPase

Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6056), p.678-683

2011

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mTOR gets greasy: lysosomal sensing of cholesterol

Cell research, 2023-03, Vol.33 (3), p.189-190

2023

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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1

Molecular cell, 2013-11, Vol.52 (4), p.495-505

2013

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Reductive stress in cancer: coming out of the shadows

Trends in cancer, 2024-02, Vol.10 (2), p.103-112

2024

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Size does matter: Lysosome-based signaling machine regulates cell growth

Science (American Association for the Advancement of Science), 2014-12, Vol.346 (6214), p.1191-1192

Bar-Peled, Liron

2014

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Size does matter

Science (American Association for the Advancement of Science), 2014-12, Vol.346 (6214), p.1191-1192

Bar-Peled, Liron

2014

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Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Cell, 2012-09, Vol.150 (6), p.1196-1208

2012

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A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6136), p.1100-1106

2013

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Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.PR16-PR16

2017

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Lysosome: The metabolic signaling hub

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

Identification of Galacturonic Acid-1-phosphate Kinase, a New Member of the GHMP Kinase Superfamily in Plants, and Comparison with Galactose-1-phosphate Kinase

Regulation of mTORC1 by amino acids

Chemical proteomics to study metabolism, a reductionist approach applied at the systems level

Principles and functions of metabolic compartmentalization

How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H⁺-ATPase

mTOR gets greasy: lysosomal sensing of cholesterol

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1

Reductive stress in cancer: coming out of the shadows

Size does matter: Lysosome-based signaling machine regulates cell growth

Size does matter

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer

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