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Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Basic & clinical pharmacology & toxicology, 2014-05, Vol.114 (5), p.365-376

2014

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Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

British journal of pharmacology, 2009-07, Vol.157 (6), p.892-906

2009

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Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung

British journal of pharmacology, 2010-08, Vol.160 (8), p.1985-1996

2010

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PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease

Trends in pharmacological sciences (Regular ed.), 2004-08, Vol.25 (8), p.430-436

2004

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Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

International journal of chronic obstructive pulmonary disease, 2016-01, Vol.11 (1), p.2139-2147

2016

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Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells

Respiratory research, 2006-01, Vol.7 (1), p.9-9, Article 9

2006

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Highlights of a workshop to discuss targeting inflammation in cystic fibrosis

Journal of cystic fibrosis, 2009-01, Vol.8 (1), p.1-8

2009

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Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma

The European respiratory journal, 1995-06, Vol.8 (6), p.996-1000

1995

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PDE4 Inhibitors - A Review of the Current Field

Progress in Medicinal Chemistry, 2009, Vol.47, p.37-74

2009

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Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene

British journal of pharmacology, 2004-11, Vol.143 (5), p.590-598

2004

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Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects

British journal of pharmacology, 2001-07, Vol.133 (5), p.722-729

2001

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2 PDE4 Inhibitors – A Review of the Current Field

Progress in Medicinal Chemistry, 2009, Vol.47, p.37-74

2009

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Hypoxia Amplifies the Proliferative Capacity of Distal Human Pulmonary Artery Smooth-Muscle Cells

Chest, 2005-12, Vol.128 (6), p.600S-601S

2005

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Models of respiratory disease symposium

Journal of inflammation (London, England), 2013-08, Vol.10 (S1), p.I1-I1, Article I1

2013

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Acute versus chronic administration of phosphodiesterase inhibitors on allergen‐induced pulmonary cell influx in sensitized guinea‐pigs

British journal of pharmacology, 1995-01, Vol.114 (1), p.93-98

1995

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The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti‐asthma drugs on inflammatory cell activation

British journal of pharmacology, 1996-11, Vol.119 (6), p.1255-1261

1996

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Characterisation of a refined rat model of respiratory infection with Pseudomonas aeruginosa and the effect of ciprofloxacin

Journal of cystic fibrosis, 2011-05, Vol.10 (3), p.166-174

2011

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Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis

British journal of pharmacology, 1995-12, Vol.116 (8), p.3169-3174

1995

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Possible contribution of prostaglandin E2 to the antiproliferative effect of phosphodiesterase 4 inhibitors in human mononuclear cells

Biochemical pharmacology, 1999-11, Vol.58 (9), p.1487-1495

1999

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Effects of dexamethasone on airway hyper‐responsiveness to the adenosine A1 receptor agonist cyclo‐pentyl adenosine in an allergic rabbit model

British journal of pharmacology, 1999-03, Vol.126 (6), p.1513-1521

1999

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A31 ASTHMA THERAPY: GLUCOCORTICOIDS AND BEYOND: Rpl554, A First-In-Class Dual Phosphodiesterase (pde)3/4 Inhibitor, Is Equi-Effective As A Bronchodilator To Maximal Doses Of Salbutamol In Asthmatics But With Fewer Adverse Events

American journal of respiratory and critical care medicine, 2016-01, Vol.193, p.1

2016

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D37 COPD: DEVELOPMENTAL THERAPEUTICS: A Phase I, Randomised, Double Blind, Placebo Controlled, Study To Assess The Safety, Tolerability And Pharmacokinetics Of Multiple Inhaled Doses Of Rpl554 Administered By Nebuliser To Healthy Male Subjects And Stable COPD Patients

American journal of respiratory and critical care medicine, 2016-01, Vol.193, p.1

2016

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D37 COPD: DEVELOPMENTAL THERAPEUTICS: A Phase I, Randomised, Double Blind, Placebo Controlled, Study To Assess The Safety, Tolerability And Pharmacokinetics Of Single Inhaled Doses Of The Dual Phosphodiesterase 3/4 (pde3/4) Inhibitor Rpl554 Administered By Nebuliser To Healthy Male Subjects

American journal of respiratory and critical care medicine, 2016-01, Vol.193, p.1

2016

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Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294

Pulmonary pharmacology & therapeutics, 2003-01, Vol.16 (2), p.97-104

2003

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Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung

PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells

Highlights of a workshop to discuss targeting inflammation in cystic fibrosis

Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma

PDE4 Inhibitors - A Review of the Current Field

Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene

Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects

2 PDE4 Inhibitors – A Review of the Current Field

Hypoxia Amplifies the Proliferative Capacity of Distal Human Pulmonary Artery Smooth-Muscle Cells

Models of respiratory disease symposium

Acute versus chronic administration of phosphodiesterase inhibitors on allergen‐induced pulmonary cell influx in sensitized guinea‐pigs

The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti‐asthma drugs on inflammatory cell activation

Characterisation of a refined rat model of respiratory infection with Pseudomonas aeruginosa and the effect of ciprofloxacin

Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis

Possible contribution of prostaglandin E2 to the antiproliferative effect of phosphodiesterase 4 inhibitors in human mononuclear cells

Effects of dexamethasone on airway hyper‐responsiveness to the adenosine A1 receptor agonist cyclo‐pentyl adenosine in an allergic rabbit model

A31 ASTHMA THERAPY: GLUCOCORTICOIDS AND BEYOND: Rpl554, A First-In-Class Dual Phosphodiesterase (pde)3/4 Inhibitor, Is Equi-Effective As A Bronchodilator To Maximal Doses Of Salbutamol In Asthmatics But With Fewer Adverse Events

D37 COPD: DEVELOPMENTAL THERAPEUTICS: A Phase I, Randomised, Double Blind, Placebo Controlled, Study To Assess The Safety, Tolerability And Pharmacokinetics Of Multiple Inhaled Doses Of Rpl554 Administered By Nebuliser To Healthy Male Subjects And Stable COPD Patients

D37 COPD: DEVELOPMENTAL THERAPEUTICS: A Phase I, Randomised, Double Blind, Placebo Controlled, Study To Assess The Safety, Tolerability And Pharmacokinetics Of Single Inhaled Doses Of The Dual Phosphodiesterase 3/4 (pde3/4) Inhibitor Rpl554 Administered By Nebuliser To Healthy Male Subjects

Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294

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