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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Pain (Amsterdam), 2009-03, Vol.142 (1), p.27-35

2009

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Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis

International journal for parasitology, 2017-10, Vol.47 (12), p.753-763

2017

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A novel intravenous vehicle for preclinical cardiovascular screening of small molecule drug candidates in rat

Journal of pharmacological and toxicological methods, 2016-11, Vol.82, p.62-67

2016

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A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

Biochemical pharmacology, 2012-02, Vol.83 (3), p.406-418

2012

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Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs

American journal of physiology. Heart and circulatory physiology, 2008-01, Vol.294 (1), p.H238-H248

2008

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Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.928-937

2009

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Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.217-226

2007

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ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

Journal of cardiovascular pharmacology, 2009-02, Vol.53 (2), p.173-178

2009

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Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H3 Receptor Inverse Agonists

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5439-5448

2007

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Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade

American journal of physiology. Heart and circulatory physiology, 2006-06, Vol.290 (6), p.H2554

2006

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Differential Inhibition of Renin mRNA Expression by Paricalcitol and Calcitriol in C57/BL6 Mice

Nephron. Physiology, 2007-01, Vol.106 (4), p.p76-p81

2007

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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats

The Journal of pharmacology and experimental therapeutics, 2016-10, Vol.359 (1), p.151-158

2016

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Effects of amrinone, atenolol, itraconazole, and pimobendan on left ventricular function in the anesthetized dog

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.186-186

2015

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Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O 2 consumption in dogs

American journal of physiology. Heart and circulatory physiology, 2008-01, Vol.294 (1), p.H238-H248

2008

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Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4857-4861

2013

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Role of residual CB1 receptor agonist activity in the hemodynamic profile of CB2 agonists

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e18-e18

2011

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Characterization of the Cardiovascular Profile of Two Novel Ca2+ Channels Blockers

The FASEB journal, 2011, Vol.25, p.1021.14-1021.14

2011

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Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H 3 Receptor Inverse Agonists

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5439-5448

2007

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Characterization of the Cardiovascular Profile of Two Novel Ca 2+ Channels Blockers

The FASEB journal, 2011-04, Vol.25 (S1)

2011

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Comprehensive Hemodynamic Assessment of Levosimendan and its Two Metabolites (OR‐1896 and OR‐1855) in the Anesthetized Dog

The FASEB journal, 2007, Vol.21 (6), p.A798-A798

2007

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Use of drug efflux transporter knockout mice to differentiate peripheral from centrally-mediated cardiovascular effects

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e52-e52

2011

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Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs

American journal of physiology. Heart and circulatory physiology, 2008, Vol.63 (1)

2008

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Blood pressure regulation by ET A and ET B receptors in conscious, telemetry-instrumented mice and role of ET A in hypertension produced by selective ET B blockade

American journal of physiology. Heart and circulatory physiology, 2006-06, Vol.290 (6), p.H2554-H2559

2006

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Supraspinal and spinal delta2 opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha2 adrenoceptors

Pain (Amsterdam), 1999-10, Vol.83 (1), p.47-55

1999

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis

A novel intravenous vehicle for preclinical cardiovascular screening of small molecule drug candidates in rat

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs

Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition

Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet

ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H3 Receptor Inverse Agonists

Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade

Differential Inhibition of Renin mRNA Expression by Paricalcitol and Calcitriol in C57/BL6 Mice

Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats

Effects of amrinone, atenolol, itraconazole, and pimobendan on left ventricular function in the anesthetized dog

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O 2 consumption in dogs

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists

Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain

Role of residual CB1 receptor agonist activity in the hemodynamic profile of CB2 agonists

Characterization of the Cardiovascular Profile of Two Novel Ca2+ Channels Blockers

Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H 3 Receptor Inverse Agonists

Characterization of the Cardiovascular Profile of Two Novel Ca 2+ Channels Blockers

Comprehensive Hemodynamic Assessment of Levosimendan and its Two Metabolites (OR‐1896 and OR‐1855) in the Anesthetized Dog

Use of drug efflux transporter knockout mice to differentiate peripheral from centrally-mediated cardiovascular effects

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs

Blood pressure regulation by ET A and ET B receptors in conscious, telemetry-instrumented mice and role of ET A in hypertension produced by selective ET B blockade

Supraspinal and spinal delta2 opioid receptor-mediated antinociceptive synergy is mediated by spinal alpha2 adrenoceptors

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