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Targeting xenobiotic receptors PXR and CAR in human diseases

Drug discovery today, 2015-05, Vol.20 (5), p.618-628

2015

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Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Biochemical pharmacology, 2013-09, Vol.86 (6), p.824-835

2013

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Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Biochemical pharmacology, 2014-11, Vol.92 (2), p.389-402

2014

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Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity

Bioorganic & medicinal chemistry letters, 2019-11, Vol.29 (22), p.126676, Article 126676

2019

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Modulation of xenobiotic receptors by steroids

Molecules, 2013-06, Vol.18 (7), p.7389-7406

2013

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PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins

Biology, 2015-02, Vol.4 (1), p.88-103

2015

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Novel ligands for human pregnane X receptor differentially regulate CYP3A4 promoter activity (579.1)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases

Pharmacology & therapeutics (Oxford), 2021-05, Vol.221, p.107747-107747, Article 107747

2021

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Selective Inhibition of the Hsp90α Isoform

Angewandte Chemie International Edition, 2021-05, Vol.60 (19), p.10547-10551

International ed. in English, 2021

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The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1545-1557

2021

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Synthesis and evaluation of 3′- and 4′-substituted cyclohexyl noviomimetics that modulate mitochondrial respiration

Bioorganic & medicinal chemistry, 2022-09, Vol.70, p.116940-116940, Article 116940

2022

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Structure‐Based Design, Synthesis, and Biological Evaluation of Hsp90β‐Selective Inhibitors

Chemistry : a European journal, 2021-10, Vol.27 (59), p.14747-14764

2021

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Mitochondrial-targeted Hsp90 C-terminal Inhibitors that Manifest Anticancer Activities

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (22), p.126676-126676

2019

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Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding

Biochemical pharmacology, 2016-03, Vol.104, p.131-138

2016

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Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation

ACS medicinal chemistry letters, 2022-05, Vol.13 (5), p.827-832

2022

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Front Cover: Rational Design and Identification of Harmine‐Inspired, N‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System (ChemMedChem 4/2022)

ChemMedChem, 2022-02, Vol.17 (4), p.n/a

2022

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Rational Design and Identification of Harmine‐Inspired, N‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System

ChemMedChem, 2022-02, Vol.17 (4), p.e202100512-n/a

2022

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A Novel Method of Production and Biophysical Characterization of the Catalytic Domain of Yeast Oligosaccharyl Transferase

Biochemistry (Easton), 2010-02, Vol.49 (6), p.1115-1126

2010

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Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein

Biochemical and biophysical research communications, 2011-08, Vol.411 (4), p.792-797

2011

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Biological Evaluation of 5′‑(N‑Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors

ACS medicinal chemistry letters, 2021-03, Vol.12 (3), p.373-379

2021

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Probing the Structure and Function of Human Glutaminase-Interacting Protein: A Possible Target for Drug Design

Biochemistry (Easton), 2008-09, Vol.47 (35), p.9208-9219

2008

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Understanding protein‐protein interaction network: a case study with glutaminase interacting protein

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Novel Phage Displayed Human GIP‐Binding Peptides Inhibit the Growth of Cancer Cells

The FASEB journal, 2011-04, Vol.25 (S1), p.963.1-963.1

2011

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New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP)

Biochemical and biophysical research communications, 2013-03, Vol.432 (1), p.10-15

2013

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Promiscuous Binding at the Crossroads of Numerous Cancer Pathways: Insight from the Binding of Glutaminase Interacting Protein with Glutaminase L

Biochemistry (Easton), 2011-05, Vol.50 (17), p.3528-3539

2011

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Targeting xenobiotic receptors PXR and CAR in human diseases

Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1

Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity

Modulation of xenobiotic receptors by steroids

PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins

Novel ligands for human pregnane X receptor differentially regulate CYP3A4 promoter activity (579.1)

Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases

Selective Inhibition of the Hsp90α Isoform

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition

Synthesis and evaluation of 3′- and 4′-substituted cyclohexyl noviomimetics that modulate mitochondrial respiration

Structure‐Based Design, Synthesis, and Biological Evaluation of Hsp90β‐Selective Inhibitors

Mitochondrial-targeted Hsp90 C-terminal Inhibitors that Manifest Anticancer Activities

Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding

Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation

Front Cover: Rational Design and Identification of Harmine‐Inspired, N‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System (ChemMedChem 4/2022)

Rational Design and Identification of Harmine‐Inspired, N‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System

A Novel Method of Production and Biophysical Characterization of the Catalytic Domain of Yeast Oligosaccharyl Transferase

Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein

Biological Evaluation of 5′‑(N‑Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors

Probing the Structure and Function of Human Glutaminase-Interacting Protein: A Possible Target for Drug Design

Understanding protein‐protein interaction network: a case study with glutaminase interacting protein

Novel Phage Displayed Human GIP‐Binding Peptides Inhibit the Growth of Cancer Cells

New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP)

Promiscuous Binding at the Crossroads of Numerous Cancer Pathways: Insight from the Binding of Glutaminase Interacting Protein with Glutaminase L

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