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Radical SAM Enzymes

Bandarian, Vahe

1, 2018

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Elucidation of the substrate of tRNA-modifying enzymes MnmEG leads to in vitro reconstitution of an evolutionarily conserved uridine hypermodification

The Journal of biological chemistry, 2022-11, Vol.298 (11), p.102548-102548, Article 102548

2022

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QueE: A Radical SAM Enzyme Involved in the Biosynthesis of 7-Deazapurine Containing Natural Products

Methods in enzymology, 2018, Vol.606, p.95-118

2018

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Site-Specific Profiling of 4‑Thiouridine Across Transfer RNA Genes in Escherichia coli

ACS omega, 2022-02, Vol.7 (5), p.4011-4025

2022

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Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7‑Deazapurines

Biochemistry (Easton), 2013-01, Vol.52 (1), p.188-198

2013

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Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Current opinion in chemical biology, 2013-08, Vol.17 (4), p.613-618

2013

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Revealing the Quaternary Structure of a Heterogeneous Noncovalent Protein Complex through Surface-Induced Dissociation

Analytical chemistry (Washington), 2011-04, Vol.83 (8), p.2862-2865

2011

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Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (18), p.7368-7372

2011

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Insights into the Mechanism of Installation of 5‑Carboxymethylaminomethyl Uridine Hypermodification by tRNA-Modifying Enzymes MnmE and MnmG

Journal of the American Chemical Society, 2023-12, Vol.145 (49), p.26947-26961

2023

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Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron–Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine

Biochemistry (Easton), 2015-08, Vol.54 (31), p.4927-4935

2015

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Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders

The Journal of biological chemistry, 2015-04, Vol.290 (17), p.10994-11007

2015

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An informatic framework for decoding protein complexes by top-down mass spectrometry

Nature methods, 2016-03, Vol.13 (3), p.237

2016

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Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

ACS central science, 2015-12, Vol.1 (9), p.477-487

2015

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The Structural Basis for Recognition of the PreQ0 Metabolite by an Unusually Small Riboswitch Aptamer Domain

The Journal of biological chemistry, 2009-04, Vol.284 (17), p.11012-11016

2009

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Exploring the biosynthesis of hypermodified bases one step at a time

The FASEB journal, 2018-04, Vol.32 (S1), p.381.1-381.1

Bandarian, Vahe

2018

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The Deazapurine Biosynthetic Pathway Revealed: In Vitro Enzymatic Synthesis of PreQ0 from Guanosine 5′-Triphosphate in Four Steps

Biochemistry (Easton), 2009-05, Vol.48 (18), p.3847-3852

2009

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Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates

PloS one, 2013-08, Vol.8 (8), p.e72372-e72372

2013

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Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily

The Journal of biological chemistry, 2014-08, Vol.289 (34), p.23641-23652

2014

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Preface to Methods in Enzymology, Volume 606

Methods in enzymology, 2018-01, Vol.606, p.xv-xvi

Bandarian, Vahe

2018

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Journey on the Radical SAM Road as an Accidental Pilgrim

ACS bio & med chem au, 2022-06, Vol.2 (3), p.187-195

Bandarian, Vahe

2022

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A Promiscuous rSAM Enzyme Enables Diverse Peptide Cross-linking

ACS bio & med chem au, 2023-12, Vol.3 (6), p.480-493

2023

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Enzymes Involved In Secondary Metabolism And RNA Modification

The FASEB journal, 2016-04, Vol.30 (S1)

Bandarian, Vahe

2016

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TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases

Methods in enzymology, 2018, Vol.606, p.119-153

2018

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Radical SAM enzymes involved in the biosynthesis of purine-based natural products

Biochimica et biophysica acta, 2012-11, Vol.1824 (11), p.1245-1253

Bandarian, Vahe

2012

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The Copper-Inducible cin Operon Encodes an Unusual Methionine-Rich Azurin-Like Protein and a Pre-Q0 Reductase in Pseudomonas putida KT2440

Journal of Bacteriology, 2007-07, Vol.189 (14), p.5361-5371

2007

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Radical SAM Enzymes

Elucidation of the substrate of tRNA-modifying enzymes MnmEG leads to in vitro reconstitution of an evolutionarily conserved uridine hypermodification

QueE: A Radical SAM Enzyme Involved in the Biosynthesis of 7-Deazapurine Containing Natural Products

Site-Specific Profiling of 4‑Thiouridine Across Transfer RNA Genes in Escherichia coli

Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7‑Deazapurines

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Revealing the Quaternary Structure of a Heterogeneous Noncovalent Protein Complex through Surface-Induced Dissociation

Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification

Insights into the Mechanism of Installation of 5‑Carboxymethylaminomethyl Uridine Hypermodification by tRNA-Modifying Enzymes MnmE and MnmG

Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron–Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine

Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders

An informatic framework for decoding protein complexes by top-down mass spectrometry

Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

The Structural Basis for Recognition of the PreQ0 Metabolite by an Unusually Small Riboswitch Aptamer Domain

Exploring the biosynthesis of hypermodified bases one step at a time

The Deazapurine Biosynthetic Pathway Revealed: In Vitro Enzymatic Synthesis of PreQ0 from Guanosine 5′-Triphosphate in Four Steps

Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates

Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily

Preface to Methods in Enzymology, Volume 606

Journey on the Radical SAM Road as an Accidental Pilgrim

A Promiscuous rSAM Enzyme Enables Diverse Peptide Cross-linking

Enzymes Involved In Secondary Metabolism And RNA Modification

TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases

Radical SAM enzymes involved in the biosynthesis of purine-based natural products

The Copper-Inducible cin Operon Encodes an Unusual Methionine-Rich Azurin-Like Protein and a Pre-Q0 Reductase in Pseudomonas putida KT2440

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