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Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

Journal of the American Chemical Society, 2010-02, Vol.132 (5), p.1523-1525

2010

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Antibody Conjugation Approach Enhances Breadth and Potency of Neutralization of Anti-HIV-1 Antibodies and CD4-IgG

Journal of Virology, 2013-05, Vol.87 (9), p.4985-4993

2013

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Facile and Stabile Linkages through Tyrosine: Bioconjugation Strategies with the Tyrosine-Click Reaction

Bioconjugate chemistry, 2013-04, Vol.24 (4), p.520-532

2013

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Mechanism of action of DSP-7888 (adegramotide/nelatimotide) Emulsion, a peptide-based therapeutic cancer vaccine with the potential to turn up the heat on non-immunoreactive tumors

Clinical & translational oncology, 2023-02, Vol.25 (2), p.396-407

2023

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A Convenient One-Pot Preparation of N-Substituted 4-Phenylpiperidines

Heterocycles, 2008, Vol.75 (1), p.183

2008

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Targeting Tumor-Associated Macrophages with the Immune-Activating Nanomedicine for Achieving Strong Antitumor Activity with Rapid Clearance from the Body

ACS nano, 2024-08, Vol.18 (34), p.23757

2024

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Formylbenzene Diazonium Hexafluorophosphate Reagent for Tyrosine-Selective Modification of Proteins and the Introduction of a Bioorthogonal Aldehyde

Bioconjugate chemistry, 2012-12, Vol.23 (12), p.2321-2328

2012

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Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL-Rearrangement or NPM1 Mutation

Blood, 2021-11, Vol.138 (Supplement 1), p.3339-3339

2021

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Rate Enhancement of the Pauson-Khand Reaction by Primary Amines

Angewandte Chemie (International ed.), 1997-01, Vol.36 (24), p.2801-2804

1997

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Abstract 223: Antibody intracellular activated drug conjugate (AiADC) as novel ADC technology

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.223-223

2019

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Abstract 5480: Colorectal cancer cell lines harboring mutation in Wnt/β-catenin pathway shows enhanced sensitivity to the stearoyl-CoA desaturase (SCD) inhibitor, DSP-0692

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5480-5480

2018

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Abstract 3069: DSP-0692, a novel and selective stearoyl-CoA desaturase (SCD) inhibitor targeting cancer stem cells

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3069-3069

2018

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Abstract 3595: DSP-0692, a selective SCD inhibitor, enhances the anti-tumor activity of anti-PD1 antibody

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3595-3595

2019

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DSP-7888, a Novel Cocktail Design of WT1 Peptide Vaccine, and Its Combinational Immunotherapy with Immune Checkpoint-Blocking Antibody Against PD-1

Blood, 2016-12, Vol.128 (22), p.4715-4715

2016

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Abstract 5724: Preclinical evaluation of a novel CHK1 inhibitor encapsulated within the liposome, SMP-3124, for the treatment of solid cancer

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5724-5724

2024

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In vivo programming of endogenous antibodies via oral administration of adaptor ligands

Bioorganic & medicinal chemistry, 2017-11, Vol.25 (21), p.5952-5961

2017

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A Practical Synthesis of 1-Alkyl-3-amino-4-aryl-1,8-naphthyridin-2-(1H)-one, a Partial Structure of ACAT Inhibitor SMP-797

Heterocycles, 2005-11, Vol.65 (11), p.2763

2005

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Synthesis and structure–activity relationships of N-(4-amino-2,6-diisopropylphenyl)- N’-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4636-4646

2009

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A Novel Class of Antihyperlipidemic Agents with Low Density Lipoprotein Receptor Up-Regulation via the Adaptor Protein Autosomal Recessive Hypercholesterolemia

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3284-3295

2010

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Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: Dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1062-1065

2009

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Synthesis of SMP-797: a new potent ACAT inhibitor

Tetrahedron, 2005-10, Vol.61 (42), p.10081-10092

2005

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Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1 H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.44-48

2006

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A convenient synthesis of 4-aryl-1,8-naphthyridin-2(1 H)-ones by the Suzuki coupling

Tetrahedron letters, 2003-08, Vol.44 (32), p.6021-6023

2003

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Novel decomplexation method for alkyne–Co2(CO)6 complexes

Journal of organometallic chemistry, 1998-03, Vol.554 (2), p.163-166

1998

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An Efficient Method for Generation of α-Oxoketenes: Cycloreversion of Enolized Meldrum's Acid Derivatives

Tetrahedron letters, 1997-09, Vol.38 (38), p.6689-6692

1997

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Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

Antibody Conjugation Approach Enhances Breadth and Potency of Neutralization of Anti-HIV-1 Antibodies and CD4-IgG

Facile and Stabile Linkages through Tyrosine: Bioconjugation Strategies with the Tyrosine-Click Reaction

Mechanism of action of DSP-7888 (adegramotide/nelatimotide) Emulsion, a peptide-based therapeutic cancer vaccine with the potential to turn up the heat on non-immunoreactive tumors

A Convenient One-Pot Preparation of N-Substituted 4-Phenylpiperidines

Targeting Tumor-Associated Macrophages with the Immune-Activating Nanomedicine for Achieving Strong Antitumor Activity with Rapid Clearance from the Body

Formylbenzene Diazonium Hexafluorophosphate Reagent for Tyrosine-Selective Modification of Proteins and the Introduction of a Bioorthogonal Aldehyde

Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL-Rearrangement or NPM1 Mutation

Rate Enhancement of the Pauson-Khand Reaction by Primary Amines

Abstract 223: Antibody intracellular activated drug conjugate (AiADC) as novel ADC technology

Abstract 5480: Colorectal cancer cell lines harboring mutation in Wnt/β-catenin pathway shows enhanced sensitivity to the stearoyl-CoA desaturase (SCD) inhibitor, DSP-0692

Abstract 3069: DSP-0692, a novel and selective stearoyl-CoA desaturase (SCD) inhibitor targeting cancer stem cells

Abstract 3595: DSP-0692, a selective SCD inhibitor, enhances the anti-tumor activity of anti-PD1 antibody

DSP-7888, a Novel Cocktail Design of WT1 Peptide Vaccine, and Its Combinational Immunotherapy with Immune Checkpoint-Blocking Antibody Against PD-1

Abstract 5724: Preclinical evaluation of a novel CHK1 inhibitor encapsulated within the liposome, SMP-3124, for the treatment of solid cancer

In vivo programming of endogenous antibodies via oral administration of adaptor ligands

A Practical Synthesis of 1-Alkyl-3-amino-4-aryl-1,8-naphthyridin-2-(1H)-one, a Partial Structure of ACAT Inhibitor SMP-797

Synthesis and structure–activity relationships of N-(4-amino-2,6-diisopropylphenyl)- N’-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents

A Novel Class of Antihyperlipidemic Agents with Low Density Lipoprotein Receptor Up-Regulation via the Adaptor Protein Autosomal Recessive Hypercholesterolemia

Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: Dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression

Synthesis of SMP-797: a new potent ACAT inhibitor

Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1 H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

A convenient synthesis of 4-aryl-1,8-naphthyridin-2(1 H)-ones by the Suzuki coupling

Novel decomplexation method for alkyne–Co2(CO)6 complexes

An Efficient Method for Generation of α-Oxoketenes: Cycloreversion of Enolized Meldrum's Acid Derivatives

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