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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

The Journal of biological chemistry, 2021-08, Vol.297 (2), p.100928, Article 100928

2021

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Partial Reduction of Pyridinium Salts as a Versatile Route to Dihydropyridones

Organic letters, 2005-02, Vol.7 (3), p.435-437

2005

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Copper-catalyzed rearrangement of oximes into primary amides

Tetrahedron letters, 2011-08, Vol.52 (33), p.4252-4255

2011

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Iridium-catalyzed formylation of amines with paraformaldehyde

Tetrahedron letters, 2010-11, Vol.51 (44), p.5804-5806

2010

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In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

Scientific reports, 2017-09, Vol.7 (1), p.10806-11, Article 10806

2017

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Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6890-6896

2013

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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4433-4437

2008

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The discovery of the benzazepine class of histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6897-6901

2013

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Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2- a]pyridine acid pump antagonists (APAs)

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3602-3606

2009

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The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4373-4376

2008

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(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3402-3406

2005

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The ammonia-free partial reduction of substituted pyridinium salts

Organic & biomolecular chemistry, 2006-01, Vol.4 (6), p.1071-1084

2006

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(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3407-3411

2005

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Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2494-2501

1990

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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6706-6717

2007

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Synthesis of the potent influenza neuraminidase inhibitor 4-guanidino Neu5Ac2en. X-Ray molecular structure of 5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-erythro-L-gluco-nononic acid

Journal of the Chemical Society, Perkin Transactions 1, 1995 (9), p.1173

1995

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Synthesis and antiviral activity of some 3'-C-difluoromethyl- and 3'-deoxy-3'-C-fluoromethyl nucleosides

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2488-2494

1990

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Functionalised pyrrolidinones derived from ( S)-pyroglutamic acid

Tetrahedron, 1996, Vol.52 (10), p.3719-3740

1996

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Corrigendum to “(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors” [Bioorg. Med. Chem. Lett. 15 (2005) 3402–3406]

Bioorganic & medicinal chemistry letters, 2015-03, Vol.25 (5), p.1151-1151

2015

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A concise approach to functionalised, homochiral pyrrolidinones

Tetrahedron: asymmetry, 1995, Vol.6 (2), p.337-340

1995

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The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3274-3281

1994

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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H 3 Receptor Antagonists

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6706-6717

2007

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A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3120-3128

1993

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Synthesis of 6-, 7- and 8-carbon sugar analogues of potent anti-influenza 2,3-didehydro-2,3-dideoxy-N-acetylneuraminic acid derivatives

Journal of the Chemical Society, Perkin Transactions 1, 1995 (9), p.1181

1995

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The Squalestatins: Synthesis and Biological Activity of Some C3-Modified Analogs; Replacement of a Carboxylic Acid or Methyl Ester with an Isoelectronic Heterocyclic Functionality

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3502-3513

1995

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

Partial Reduction of Pyridinium Salts as a Versatile Route to Dihydropyridones

Copper-catalyzed rearrangement of oximes into primary amides

Iridium-catalyzed formylation of amines with paraformaldehyde

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

The discovery of the benzazepine class of histamine H3 receptor antagonists

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2- a]pyridine acid pump antagonists (APAs)

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

The ammonia-free partial reduction of substituted pyridinium salts

(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors

Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides

4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists

Synthesis of the potent influenza neuraminidase inhibitor 4-guanidino Neu5Ac2en. X-Ray molecular structure of 5-acetamido-4-amino-2,6-anhydro-3,4,5-trideoxy-D-erythro-L-gluco-nononic acid

Synthesis and antiviral activity of some 3'-C-difluoromethyl- and 3'-deoxy-3'-C-fluoromethyl nucleosides

Functionalised pyrrolidinones derived from ( S)-pyroglutamic acid

Corrigendum to “(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors” [Bioorg. Med. Chem. Lett. 15 (2005) 3402–3406]

A concise approach to functionalised, homochiral pyrrolidinones

The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs

4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H 3 Receptor Antagonists

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships

Synthesis of 6-, 7- and 8-carbon sugar analogues of potent anti-influenza 2,3-didehydro-2,3-dideoxy-N-acetylneuraminic acid derivatives

The Squalestatins: Synthesis and Biological Activity of Some C3-Modified Analogs; Replacement of a Carboxylic Acid or Methyl Ester with an Isoelectronic Heterocyclic Functionality

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