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Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast

Biochimica et biophysica acta, 2010-02, Vol.1801 (2), p.156-162

2010

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In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity

Biochimica et biophysica acta, 2003-07, Vol.1633 (1), p.68-74

2003

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Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae

Biochimica et biophysica acta, 2008-08, Vol.1781 (8), p.359-366

2008

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Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast

Lipids, 2002-12, Vol.37 (12), p.1171-1176

2002

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Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies

Biochemical Society transactions, 2005-11, Vol.33 (Pt 5), p.1202-1205

2005

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Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles

The Journal of biological chemistry, 2002-01, Vol.277 (4), p.2406-2412

2002

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Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.35904-35913

2005

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Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1931-1934

2004

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Inhibition of sterol biosynthesis in Saccharomyces cerevisiae and Candida albicans by 22,23-epoxy-2-aza-2,3-dihydrosqualene and the corresponding N-oxide

Antimicrobial Agents and Chemotherapy, 1994-09, Vol.38 (9), p.1904-1908

1994

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Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii

Lipids, 2004-10, Vol.39 (10), p.1007

2004

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Systematic analysis of yeast strains with possible defects in lipid metabolism

Yeast (Chichester, England), 1999-05, Vol.15 (7), p.601-614

1999

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Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors

European journal of medicinal chemistry, 2004-11, Vol.39 (11), p.917-924

2004

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Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene‐hopene cyclases

Lipids, 2001-06, Vol.36 (6), p.629-636

2001

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Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies

Biochemical Society transactions, 2005-11, Vol.33 (5), p.1202

2005

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Synthesis and biological activity of 19-azasqualene 2,3-epoxide as inhibitor of 2,3-oxidosqualene cyclase

European journal of medicinal chemistry, 1993, Vol.28 (9), p.675-682

1993

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Access of the Substrate to the Active Site of Yeast Oxidosqualene Cyclase: An Inhibition and Site-Directed Mutagenesis Approach

Chembiochem : a European journal of chemical biology, 2005-12, Vol.6 (12), p.2221-2228

2005

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Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae

Lipids, 2005-12, Vol.40 (12), p.1257-1262

2005

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Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase

Lipids, 2005-07, Vol.40 (7), p.729-735

2005

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Novel Squalene-Hopene Cyclase Inhibitors Derived from Hydroxycoumarins and Hydroxyacetophenones

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(10), pp.1171-1174

2004

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Inhibition of Bovine β-Trypsin by the Active-Site Titrant Nα-(N,N-Dimethylcarbamoyl)-α-Azaornithine p-Nitrophenyl Ester: A Kinetic and X-Ray Crystallographic Study

Biochemical and biophysical research communications, 1995-12, Vol.217 (2), p.437-444

1995

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The squalene‐2,3‐epoxide cyclase as a model for the development of new drugs

Lipids, 1986-01, Vol.21 (1), p.31-38

1986

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Stereospecific syntheses of trans-vinyldioxidosqualene and β-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors

Bioorganic & medicinal chemistry, 2000, Vol.8 (1), p.223-232

2000

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29-Methylidene-2,3-oxidosqualene Derivatives as Stereospecific Mechanism-Based Inhibitors of Liver and Yeast Oxidosqualene Cyclase

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.540-554

1998

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Rationally designed inhibitors as tools for comparing the mechanism of squalene‐hopene cyclase with oxidosqualene cyclase

Lipids, 2000-03, Vol.35 (3), p.297-303

2000

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22,23-Epoxy-2-aza-2,3-dihydrosqualene derivatives: potent new inhibitors of squalene 2,3-oxide-lanosterol cyclase

Farmaco (Società chimica italiana : 1989), 1990-09, Vol.45 (9), p.965

1990

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Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast

In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity

Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae

Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast

Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies

Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles

Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis

Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors

Inhibition of sterol biosynthesis in Saccharomyces cerevisiae and Candida albicans by 22,23-epoxy-2-aza-2,3-dihydrosqualene and the corresponding N-oxide

Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii

Systematic analysis of yeast strains with possible defects in lipid metabolism

Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors

Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene‐hopene cyclases

Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies

Synthesis and biological activity of 19-azasqualene 2,3-epoxide as inhibitor of 2,3-oxidosqualene cyclase

Access of the Substrate to the Active Site of Yeast Oxidosqualene Cyclase: An Inhibition and Site-Directed Mutagenesis Approach

Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae

Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase

Novel Squalene-Hopene Cyclase Inhibitors Derived from Hydroxycoumarins and Hydroxyacetophenones

Inhibition of Bovine β-Trypsin by the Active-Site Titrant Nα-(N,N-Dimethylcarbamoyl)-α-Azaornithine p-Nitrophenyl Ester: A Kinetic and X-Ray Crystallographic Study

The squalene‐2,3‐epoxide cyclase as a model for the development of new drugs

Stereospecific syntheses of trans-vinyldioxidosqualene and β-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors

29-Methylidene-2,3-oxidosqualene Derivatives as Stereospecific Mechanism-Based Inhibitors of Liver and Yeast Oxidosqualene Cyclase

Rationally designed inhibitors as tools for comparing the mechanism of squalene‐hopene cyclase with oxidosqualene cyclase

22,23-Epoxy-2-aza-2,3-dihydrosqualene derivatives: potent new inhibitors of squalene 2,3-oxide-lanosterol cyclase

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