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Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema

British journal of pharmacology, 2008-03, Vol.153 (5), p.947-955

2008

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Leflunomide interferes with pyrimidine nucleotide biosynthesis

Inflammation research, 1995-08, Vol.44 (8), p.317-322

1995

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Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds

The Journal of biological chemistry, 2001-12, Vol.276 (51), p.48118-48126

2001

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Antifungal rapamycin analogues with reduced immunosuppressive activity

Bioorganic & medicinal chemistry letters, 2000-07, Vol.10 (13), p.1405-1408

2000

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Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents

Agents and Actions, 1989-03, Vol.26 (3-4), p.335-341

1989

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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Journal of medicinal chemistry, 2007-04, Vol.50 (8), p.1983-1987

2007

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Inhibition of p56(lck) tyrosine kinase by isothiazolones

Archives of biochemistry and biophysics, 1999-04, Vol.364 (1), p.19-29

1999

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Journal of the American Chemical Society, 2003-04, Vol.125 (14), p.4087-4096

2003

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Acne-like Chronic Inflammatory Activity of Propionibacterium acnes Preparations in an Animal Model: Correlation with Ability to Stimulate the Reticuloendothelial System

Journal of investigative dermatology, 1985-09, Vol.85 (3), p.255-258

1985

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Intradermal Injection of Propionibacterium acnes: A Model of Inflammation Relevant to Acne

Journal of investigative dermatology, 1984-11, Vol.83 (5), p.394-398

1984

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Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4232-4235

2003

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Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3437-3440

2003

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5543-5546

2004

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Ex vivo assessment of immunosuppression in undiluted whole blood from pigs dosed with tacrolimus (FK506)

Clinical immunology (Orlando, Fla.), 1999-01, Vol.90 (1), p.133

1999

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Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3947-3950

2003

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Inhibition of Human Epidermal Transglutaminases In Vitro and In Vivo by Tyrosinamidomethyl Dihydrohaloisoxazoles

Journal of investigative dermatology, 1991-07, Vol.97 (1), p.156-158

1991

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2093-2103

2003

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Potent, selective inhibitors of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1887-1890

2003

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Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3129-3132

2003

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AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction

Molecular therapy. Methods & clinical development, 2020-09, Vol.18, p.607-619

2020

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

Scientific reports, 2019-11, Vol.9 (1), p.16947-14, Article 16947

2019

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Evidence for Shelf Acidification During the Onset of the Paleocene‐Eocene Thermal Maximum

Paleoceanography and paleoclimatology, 2018-12, Vol.33 (12), p.1408-1426

2018

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Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Biochemistry (Easton), 2006-06, Vol.45 (24), p.7474-7482

2006

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Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema

Leflunomide interferes with pyrimidine nucleotide biosynthesis

Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds

Antifungal rapamycin analogues with reduced immunosuppressive activity

Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Inhibition of p56(lck) tyrosine kinase by isothiazolones

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Acne-like Chronic Inflammatory Activity of Propionibacterium acnes Preparations in an Animal Model: Correlation with Ability to Stimulate the Reticuloendothelial System

Intradermal Injection of Propionibacterium acnes: A Model of Inflammation Relevant to Acne

Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Ex vivo assessment of immunosuppression in undiluted whole blood from pigs dosed with tacrolimus (FK506)

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Inhibition of Human Epidermal Transglutaminases In Vitro and In Vivo by Tyrosinamidomethyl Dihydrohaloisoxazoles

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Potent, selective inhibitors of protein tyrosine phosphatase 1B

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Evidence for Shelf Acidification During the Onset of the Paleocene‐Eocene Thermal Maximum

Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

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