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Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl‑1 Inhibitor (AZD5991) and Other Synthetic Macrocycles
Journal of medicinal chemistry, 2019-11, Vol.62 (21), p.9418-9437
2019
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Correction to “Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl‑1 Inhibitor (AZD5991) and Other Synthetic Macrocycles”
Journal of medicinal chemistry, 2021-03, Vol.64 (5), p.2849-2849
2021
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Structural and Physicochemical Features of Oral PROTACs
Journal of medicinal chemistry, 2024-07
2024
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Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics
Magnetic Resonance : (Göttingen), 2021-06, Vol.2 (1), p.489-498
2021
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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14498-14512
2021
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Discovery, preclinical validation and early human imaging with [11C]AZ14193391 – the first blood-brain barrier permeable and subtype selective PARP1 PET radioligand
Nuclear medicine and biology, 2023-11, Vol.126-127, p.108465, Article 108465
2023
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Abstract 296: Structure-based and property-based drug design of AZD5305, a highly selective PARP1 inhibitor and trapper
Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.296-296
2021
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Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors
Bioorganic & medicinal chemistry letters, 2023-07, Vol.91, p.129352-129352, Article 129352
2023
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Discovery of 5‑{4-[(7-Ethyl-6-oxo‑5,6-dihydro‑1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}‑N‑methyl­pyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14498-14512
2021
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Optimization of a series of potent, selective and orally bioavailable SYK inhibitors
Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (19), p.127433, Article 127433
2020
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Abstract 5076: Evaluation of the CNS penetration of a next generation PARP inhibitor, AZD9574, in cynomolgus monkey using positron emission tomography
Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5076-5076
2022
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Abstract 6302: Structure-based and property-based drug design of AZD9574, a CNS penetrant PARP1 selective inhibitor and trapper
Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.6302-6302
2022
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Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease
Neurobiology of disease, 2024-01, Vol.190, p.106376-106376, Article 106376
2024
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Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease
Neurobiology of disease, 2020-07, Vol.141, p.104943-104943, Article 104943
2020
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Corrigendum to “Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease” [Neurobiology of Disease, 2024 Jan:190:106376]
Neurobiology of disease, 2024-04, Vol.193, p.106444-106444, Article 106444
2024
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Empowerment and Constraint: Design of a Homecare Worker Training Program
International journal of designs for learning, 2018-05, Vol.9 (1), p.149-157
2018
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Synthesis, Structure, and Ligand Exchange Reactions of Tetramethyleneethane Complexes of Cobalt
Organometallics, 2010-11, Vol.29 (22), p.5847-5858
2010
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