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Recent advances in targeted drug delivery for treatment of osteoarthritis

Current opinion in rheumatology, 2021-01, Vol.33 (1), p.94-109

2021

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Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Arthritis research & therapy, 2019-11, Vol.21 (1), p.238-238, Article 238

2019

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Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation

Arthritis research & therapy, 2022-07, Vol.24 (1), p.172-14, Article 172

2022

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Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins

Nano today, 2020-10, Vol.34, p.100898, Article 100898

2020

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Cartilage-targeting drug delivery: can electrostatic interactions help?

Nature reviews. Rheumatology, 2017-03, Vol.13 (3), p.183-193

2017

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Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery

MethodsX, 2020-01, Vol.7, p.100882-100882, Article 100882

2020

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Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage

Biophysical journal, 2022-09, Vol.121 (18), p.3542-3561

2022

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Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues

Acta biomaterialia, 2019-07, Vol.93, p.258-269

2019

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Harnessing exosomes for advanced osteoarthritis therapy

Nanoscale, 2024-10, Vol.16 (41), p.19174-19191

2024

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Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs

Journal of controlled release, 2020-02, Vol.318, p.109-123

2020

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Charge-Based Multiarm Avidin Nanoconstruct as a Platform Technology for Applications in Drug Delivery

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2394, p.537

2022

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Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2393, p.797

2022

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Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis

ACS nano, 2023-04, Vol.17 (7), p.6649-6663

2023

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Charge-based drug delivery to cartilage: Hydrophobic and not electrostatic interactions are the dominant cause of competitive binding of cationic carriers in synovial fluid

Acta biomaterialia, 2022-10, Vol.151, p.278-289

2022

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Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA

Biomaterials science, 2021-06, Vol.9 (12), p.426-4277

2021

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Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair

Tissue engineering. Part A, 2021-06, Vol.27 (11-12), p.748-760

2021

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Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Journal of visualized experiments, 2020-08 (162)

2020

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Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints

Journal of orthopaedic research, 2014-08, Vol.32 (8), p.1044-1051

2014

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Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis

Biomaterials, 2014-01, Vol.35 (1), p.538-549

2014

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Effect of dynamic loading on calcium signaling in In-Situ chondrocytes

Journal of biomechanics, 2024-09, Vol.174, p.112265, Article 112265

2024

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A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage

Journal of orthopaedic research, 2015-05, Vol.33 (5), p.660-667

2015

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Single-Dose Intra-Cartilage Delivery of Kartogenin Using a Cationic Multi-Arm Avidin Nanocarrier Suppresses Cytokine-Induced Osteoarthritis-Related Catabolism

Cartilage, 2022-04, Vol.13 (2), p.19476035221093072

2022

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Adolescent obesity incurs adult skeletal deficits in murine induced obesity model

Journal of orthopaedic research, 2023-02, Vol.41 (2), p.386-395

2023

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Bioelectricity for Drug Delivery: The Promise of Cationic Therapeutics

Bioelectricity, 2020-06, Vol.2 (2), p.68-81

2020

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Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory

Bioelectricity, 2022-12, Vol.4 (4), p.248-258

2022

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Recent advances in targeted drug delivery for treatment of osteoarthritis

Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation

Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins

Cartilage-targeting drug delivery: can electrostatic interactions help?

Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery

Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage

Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues

Harnessing exosomes for advanced osteoarthritis therapy

Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs

Charge-Based Multiarm Avidin Nanoconstruct as a Platform Technology for Applications in Drug Delivery

Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis

Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis

Charge-based drug delivery to cartilage: Hydrophobic and not electrostatic interactions are the dominant cause of competitive binding of cationic carriers in synovial fluid

Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA

Hyaluronic Acid-Based Shape-Memory Cryogel Scaffolds for Focal Cartilage Defect Repair

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints

Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis

Effect of dynamic loading on calcium signaling in In-Situ chondrocytes

A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage

Single-Dose Intra-Cartilage Delivery of Kartogenin Using a Cationic Multi-Arm Avidin Nanocarrier Suppresses Cytokine-Induced Osteoarthritis-Related Catabolism

Adolescent obesity incurs adult skeletal deficits in murine induced obesity model

Bioelectricity for Drug Delivery: The Promise of Cationic Therapeutics

Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory

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