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The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Molecular and cellular biology, 2020-06, Vol.40 (13)

2020

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NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer

Molecular and cellular biology, 2021-02, Vol.41 (2)

2021

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The cytoprotective role of the Keap1–Nrf2 pathway

Archives of toxicology, 2011-04, Vol.85 (4), p.241-272

2011

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Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells

Molecular and cellular biology, 2016-12, Vol.36 (24), p.3100-3112

2016

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Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

Cell reports (Cambridge), 2019-07, Vol.28 (3), p.746-758.e4

2019

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Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15259-15264

2013

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Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance

Redox biology, 2023-11, Vol.67, p.102904-102904, Article 102904

2023

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Monitoring Keap1–Nrf2 interactions in single live cells

Biotechnology advances, 2014-11, Vol.32 (6), p.1133-1144

2014

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Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

Molecular and cellular biology, 2016-01, Vol.36 (2), p.271-284

2016

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Novel NRF2‐activated cancer treatments utilizing synthetic lethality

IUBMB life, 2022-12, Vol.74 (12), p.1209-1231

2022

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Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Nature communications, 2017-02, Vol.8 (1), p.14577-14577, Article 14577

2017

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A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

Molecular and cellular biology, 2017-02, Vol.37 (4)

2017

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Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Biology open, 2013-08, Vol.2 (8), p.761-770

2013

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A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells

Redox biology, 2023-10, Vol.66, p.102845-102845, Article 102845

2023

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Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes

Molecular and cellular biology, 2014-10, Vol.34 (20), p.3800-3816

2014

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Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals

Journal of biochemistry (Tokyo), 2024-01

2024

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Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells

Biochemical and biophysical research communications, 2013-03, Vol.433 (1), p.58-65

2013

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Discovery of an NRF1‐specific inducer from a large‐scale chemical library using a direct NRF1‐protein monitoring system

Genes to cells : devoted to molecular & cellular mechanisms, 2015-07, Vol.20 (7), p.563-577

2015

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Hypoxia-Sensitive Reporter System for High-Throughput Screening

The Tohoku Journal of Experimental Medicine, 2015, Vol.235(2), pp.151-159

2015

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Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2

Molecular and cellular biology, 2020-10, Vol.40 (22)

2020

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NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

Cancer research (Chicago, Ill.), 2016-05, Vol.76 (10), p.3088-3096

2016

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Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity

Free radical biology & medicine, 2022-07, Vol.187, p.92-104

2022

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Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7186-7194

2015

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The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Biochemical Society transactions, 2015-08, Vol.43 (4), p.602-610

2015

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Discovery of an NRF 1‐specific inducer from a large‐scale chemical library using a direct NRF 1‐protein monitoring system

Genes to cells : devoted to molecular & cellular mechanisms, 2015-07, Vol.20 (7), p.563-577

2015

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The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer

The cytoprotective role of the Keap1–Nrf2 pathway

Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance

Monitoring Keap1–Nrf2 interactions in single live cells

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

Novel NRF2‐activated cancer treatments utilizing synthetic lethality

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells

Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes

Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals

Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells

Discovery of an NRF1‐specific inducer from a large‐scale chemical library using a direct NRF1‐protein monitoring system

Hypoxia-Sensitive Reporter System for High-Throughput Screening

Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Discovery of an NRF 1‐specific inducer from a large‐scale chemical library using a direct NRF 1‐protein monitoring system

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