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Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

Cancer cell, 2016-12, Vol.30 (6), p.879-890

2016

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An Autotaxin/Lysophosphatidic Acid/Interleukin‐6 Amplification Loop Drives Scleroderma Fibrosis

Arthritis & rheumatology (Hoboken, N.J.), 2016-12, Vol.68 (12), p.2964-2974

2016

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Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4403-4423

2017

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Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis

The Journal of pharmacology and experimental therapeutics, 2017-01, Vol.360 (1), p.1

2017

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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders

Scientific reports, 2023-08, Vol.13 (1), p.13524-13524, Article 13524

2023

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Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders

Scientific reports, 2023-11, Vol.13 (1), p.20081-20081, Article 20081

2023

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The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

Scientific reports, 2019-05, Vol.9 (1), p.7414-7414, Article 7414

2019

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

Nature immunology, 2001-02, Vol.2 (2), p.165-171

2001

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Early thymocyte development is regulated by modulation of E2A protein activity

The Journal of experimental medicine, 2001-09, Vol.194 (6), p.733-746

2001

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Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

Molecular pharmacology, 2003-10, Vol.64 (4), p.798-810

2003

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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.764

2010

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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-(( S)-1-Acetyl-2,3-dihydro-1 H-indol-2-ylmethoxy)-3- tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1 H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.213-217

2010

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Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47

The Journal of experimental medicine, 1999-12, Vol.190 (11), p.1605-1616

1999

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Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation

The Journal of pharmacology and experimental therapeutics, 2009-12, Vol.331 (3), p.1042

2009

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A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye

Clinical and Vaccine Immunology, 2009-11, Vol.16 (11), p.1654-1659

2009

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Both E12 and E47 Allow Commitment to the B Cell Lineage

Immunity (Cambridge, Mass.), 1997-02, Vol.6 (2), p.145-154

1997

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Positive and negative regulation of V(D)J recombination by the E2A proteins

The Journal of experimental medicine, 1999-01, Vol.189 (2), p.289-300

1999

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Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Kidney international, 2018-08, Vol.94 (2), p.303-314

2018

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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14721-14739

2022

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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis

The Journal of pharmacology and experimental therapeutics, 2023-08, Vol.386 (2), p.242

2023

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DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection

International immunology, 2005-11, Vol.17 (11), p.1379-1390

2005

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Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14721-14739

2022

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Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX

ACS medicinal chemistry letters, 2017-04, Vol.8 (4), p.423-427

2017

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Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis

The FASEB journal, 2016-06, Vol.30 (6), p.2435-2450

2016

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Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

Molecular pharmacology, 2015-12, Vol.88 (6), p.982-992

2015

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Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

An Autotaxin/Lysophosphatidic Acid/Interleukin‐6 Amplification Loop Drives Scleroderma Fibrosis

Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis

JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders

Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders

The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

Early thymocyte development is regulated by modulation of E2A protein activity

Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-(( S)-1-Acetyl-2,3-dihydro-1 H-indol-2-ylmethoxy)-3- tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1 H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor

Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation

A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye

Both E12 and E47 Allow Commitment to the B Cell Lineage

Positive and negative regulation of V(D)J recombination by the E2A proteins

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis

DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection

Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX

Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

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