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Targeted Covalent Inhibitors for Drug Design

Angewandte Chemie (International ed.), 2016-10, Vol.55 (43), p.13408-13421

Baillie, Thomas A.

International ed. in English, 2016

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Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Chemical research in toxicology, 2011-09, Vol.24 (9), p.1345-1410

2011

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Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

Chemical research in toxicology, 2008-01, Vol.21 (1), p.129-137

Baillie, Thomas A

2008

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Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism

DRUG METABOLISM AND PHARMACOKINETICS, 2011-01, Vol.26 (1), p.15-29

2011

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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292-306

2011

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Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

Chemical research in toxicology, 2009-02, Vol.22 (2), p.263-266

Baillie, Thomas A

2009

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The resurgence of covalent drugs

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.307-317

2011

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Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV‐50717) Compared With Tetrabenazine in Healthy Volunteers

Clinical and translational science, 2020-07, Vol.13 (4), p.707-717

2020

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An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway

Molecular pharmacology, 2012-04, Vol.81 (4), p.498-509

2012

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Approaches to mitigate the risk of serious adverse reactions in covalent drug design

Expert opinion on drug discovery, 2021-03, Vol.16 (3), p.275-287

Baillie, Thomas A.

2021

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High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies

Rapid communications in mass spectrometry, 2008-04, Vol.22 (7), p.1053-1061

2008

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Acyl glucuronides–mediators of drug-induced toxicities?

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1249-1262

Baillie, Thomas A.

2023

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Negative Ion Tandem Mass Spectrometry for the Detection of Glutathione Conjugates

Chemical research in toxicology, 2005-04, Vol.18 (4), p.630-638

2005

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The Generation, Detection, and Effects of Reactive Drug Metabolites

Medicinal research reviews, 2013-09, Vol.33 (5), p.985-1080

2013

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Organic Chemistry in Drug Discovery

Science (American Association for the Advancement of Science), 2004-03, Vol.303 (5665), p.1810-1813

2004

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Drug–protein adducts: past, present, and future

Medicinal chemistry research, 2020, Vol.29 (7), p.1093-1104

Baillie, Thomas A.

2020

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Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

Drug metabolism and disposition, 2002-05, Vol.30 (5), p.505

2002

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Safety Assessment of Acyl Glucuronides - A Simplified Paradigm

Drug metabolism and disposition, 2018-06, Vol.46 (6), p.908-912

2018

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Mechanistic studies on metabolic interactions between gemfibrozil and statins

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.1042

2002

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Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites

Toxicology and applied pharmacology, 2006-12, Vol.217 (2), p.143-152

2006

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Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

Chemical research in toxicology, 2001-01, Vol.14 (1), p.62-70

2001

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Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

Chemical research in toxicology, 2006-07, Vol.19 (7), p.889-893

Baillie, Thomas A

2006

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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

The Journal of pharmacology and experimental therapeutics, 2002-12, Vol.303 (3), p.969

2002

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Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment

Drug metabolism and disposition, 2023-06, Vol.51 (6), p.753-763

2023

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Addressing Metabolic Activation as an Integral Component of Drug Design

Drug metabolism reviews, 2006-01, Vol.38 (4), p.641-649

2006

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Targeted Covalent Inhibitors for Drug Design

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism

Managing the challenge of chemically reactive metabolites in drug development

Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

The resurgence of covalent drugs

Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV‐50717) Compared With Tetrabenazine in Healthy Volunteers

An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway

Approaches to mitigate the risk of serious adverse reactions in covalent drug design

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies

Acyl glucuronides–mediators of drug-induced toxicities?

Negative Ion Tandem Mass Spectrometry for the Detection of Glutathione Conjugates

The Generation, Detection, and Effects of Reactive Drug Metabolites

Organic Chemistry in Drug Discovery

Drug–protein adducts: past, present, and future

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

Safety Assessment of Acyl Glucuronides - A Simplified Paradigm

Mechanistic studies on metabolic interactions between gemfibrozil and statins

Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites

Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment

Addressing Metabolic Activation as an Integral Component of Drug Design

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