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Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

Chemical research in toxicology, 2004-01, Vol.17 (1), p.3-16

2004

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Drug Metabolites in Safety Testing

Toxicology and applied pharmacology, 2002-08, Vol.182 (3), p.188-196

2002

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Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Drug metabolism and disposition, 1999-03, Vol.27 (3), p.365

1999

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Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans

Drug metabolism and disposition, 2001-12, Vol.29 (12), p.1608

2001

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Roles of Human Hepatic Cytochrome P450s 2C9 and 3A4 in the Metabolic Activation of Diclofenac

Chemical research in toxicology, 1999-02, Vol.12 (2), p.192-199

1999

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Negative Ion Tandem Mass Spectrometry for the Detection of Glutathione Conjugates

Chemical research in toxicology, 2005-04, Vol.18 (4), p.630-638

2005

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Organic Chemistry in Drug Discovery

Science (American Association for the Advancement of Science), 2004-03, Vol.303 (5665), p.1810-1813

2004

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Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine

Drug metabolism and disposition, 2000-09, Vol.28 (9), p.1043

2000

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Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile

Drug metabolism and disposition, 1997-11, Vol.25 (11), p.1282

1997

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Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates

Drug metabolism and disposition, 1999-01, Vol.27 (1), p.32

1999

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Metabolic interactions between mibefradil and HMG‐CoA reductase inhibitors: an in vitro investigation with human liver preparations

British journal of clinical pharmacology, 1999-03, Vol.47 (3), p.291-298

1999

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Is the role of the small intestine in first-pass metabolism overemphasized?

Pharmacological reviews, 1999-06, Vol.51 (2), p.135

1999

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Mass spectrometry in the analysis of glutathione conjugates

Biological Mass Spectrometry, 1993-06, Vol.22 (6), p.319-325

1993

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Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4

Xenobiotica, 2004-05, Vol.34 (5), p.473-486

2004

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Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

Chemical research in toxicology, 2001-01, Vol.14 (1), p.62-70

2001

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Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion

The Journal of pharmacology and experimental therapeutics, 1994-06, Vol.269 (3), p.1166

1994

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Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques

Drug metabolism and disposition, 2001-12, Vol.29 (12), p.1614

2001

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Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations

Drug metabolism and disposition, 1991-07, Vol.19 (4), p.823

1991

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Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations

Drug metabolism and disposition, 1993-03, Vol.21 (2), p.242

1993

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Bridging cheminformatic metabolite prediction and tandem mass spectrometry

Drug discovery today, 2005-05, Vol.10 (10), p.711-717

2005

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Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme

Chemical research in toxicology, 2005-09, Vol.18 (9), p.1427-1437

2005

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Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation

Chemical research in toxicology, 2002-07, Vol.15 (7), p.907-914

2002

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Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies

The Journal of biological chemistry, 1988-09, Vol.263 (27), p.13733-13738

1988

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Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

Chemical research in toxicology, 2006-07, Vol.19 (7), p.889-893

Baillie, Thomas A

2006

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A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

The Journal of biological chemistry, 2001-01, Vol.276 (3), p.2256-2262

2001

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Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

Drug Metabolites in Safety Testing

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans

Roles of Human Hepatic Cytochrome P450s 2C9 and 3A4 in the Metabolic Activation of Diclofenac

Negative Ion Tandem Mass Spectrometry for the Detection of Glutathione Conjugates

Organic Chemistry in Drug Discovery

Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile

Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates

Metabolic interactions between mibefradil and HMG‐CoA reductase inhibitors: an in vitro investigation with human liver preparations

Is the role of the small intestine in first-pass metabolism overemphasized?

Mass spectrometry in the analysis of glutathione conjugates

Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4

Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques

Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations

Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations

Bridging cheminformatic metabolite prediction and tandem mass spectrometry

Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme

Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation

Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies

Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

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