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A simple accurate method for concentration-QTc analysis in preclinical animal models

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107528, Article 107528

2024

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The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis

Clinical and translational science, 2023-11, Vol.16 (11), p.2253-2264

2023

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QT Ratio: A simple solution to individual QT correction

Journal of pharmacological and toxicological methods, 2022-09, Vol.117, p.107211-107211, Article 107211

2022

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Improving corrected QT; Why individual correction is not enough

Journal of pharmacological and toxicological methods, 2022-01, Vol.113, p.107126-107126, Article 107126

2022

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Characterization of two novel lytic bacteriophages having lysis potential against MDR avian pathogenic Escherichia coli strains of zoonotic potential

Scientific reports, 2023-06, Vol.13 (1), p.10043-10043, Article 10043

2023

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Phenotypic characterization and genome analysis of a novel Salmonella Typhimurium phage having unique tail fiber genes

Scientific reports, 2022-04, Vol.12 (1), p.5732-5732, Article 5732

2022

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ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome

BMC endocrine disorders, 2018-05, Vol.18 (1), p.24-12, Article 24

2018

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Genome Analysis and Therapeutic Evaluation of a Novel Lytic Bacteriophage of Salmonella Typhimurium: Suggestive of a New Genus in the Subfamily Vequintavirinae

Viruses, 2022-01, Vol.14 (2), p.241

2022

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Complete Annotated Genome Sequence of Limosilactobacillus fermentum AGR1487

Microbiology resource announcements, 2021-01, Vol.10 (1)

2021

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Complete Genome Sequence of Lactobacillus fermentum Strain AGR1485, a Human Oral Isolate

Microbiology resource announcements, 2020-09, Vol.9 (36)

2020

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Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice

American journal of respiratory and critical care medicine, 2002-01, Vol.165 (2), p.229-235

2002

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A monkey torsadogen that in vitro cardiac ion channel assays would not predict

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106725, Article 106725

2020

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Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs

American journal of veterinary research, 2015-05, Vol.76 (5), p.445-453

2015

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Which QT Correction Method is Most Consistent?

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.01569

2021

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Effects of ECG Summarization Methods on the Characterization of Drug‐Induced QT Prolongation – a Demonstration of Need for Standard Methods of ECG Beat Summarization6.3.6

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Evaluating the impact of electrocardiogram analysis methods on the accurate identification of drug-induced changes to QT interval

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106798, Article 106798

2020

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Relationship of clinical adverse event reports to models of arrhythmia risk

Journal of pharmacological and toxicological methods, 2019-11, Vol.100, p.106622-106622, Article 106622

2019

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Improving the prediction of torsade de pointes risk during drug discovery and development

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Action potential plateau phase metrics in predictive models of arrhythmia potential

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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5‑Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4350-4369

2019

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Effect of autonomic blockade on ventricular repolarization shortening: Response to behavioral stimulus in paced dogs

Autonomic neuroscience, 2008-06, Vol.140 (1), p.66-71

2008

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4884-4901

2019

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Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis

American journal of physiology. Lung cellular and molecular physiology, 2000-09, Vol.279 (3), p.487-L495

2000

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A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog

Journal of pharmacological and toxicological methods, 2006-01, Vol.53 (1), p.1-10

2006

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5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

Journal of medicinal chemistry, 2019-04, Vol.62 (9), p.4350-4369

2019

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A simple accurate method for concentration-QTc analysis in preclinical animal models

The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis

QT Ratio: A simple solution to individual QT correction

Improving corrected QT; Why individual correction is not enough

Characterization of two novel lytic bacteriophages having lysis potential against MDR avian pathogenic Escherichia coli strains of zoonotic potential

Phenotypic characterization and genome analysis of a novel Salmonella Typhimurium phage having unique tail fiber genes

ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome

Genome Analysis and Therapeutic Evaluation of a Novel Lytic Bacteriophage of Salmonella Typhimurium: Suggestive of a New Genus in the Subfamily Vequintavirinae

Complete Annotated Genome Sequence of Limosilactobacillus fermentum AGR1487

Complete Genome Sequence of Lactobacillus fermentum Strain AGR1485, a Human Oral Isolate

Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice

A monkey torsadogen that in vitro cardiac ion channel assays would not predict

Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs

Which QT Correction Method is Most Consistent?

Effects of ECG Summarization Methods on the Characterization of Drug‐Induced QT Prolongation – a Demonstration of Need for Standard Methods of ECG Beat Summarization6.3.6

Evaluating the impact of electrocardiogram analysis methods on the accurate identification of drug-induced changes to QT interval

Relationship of clinical adverse event reports to models of arrhythmia risk

Improving the prediction of torsade de pointes risk during drug discovery and development

Action potential plateau phase metrics in predictive models of arrhythmia potential

5‑Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

Effect of autonomic blockade on ventricular repolarization shortening: Response to behavioral stimulus in paced dogs

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis

A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

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