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Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

British journal of cancer, 2000-02, Vol.82 (4), p.966-972

2000

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Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid

British journal of cancer, 2002-06, Vol.86 (12), p.1937-1942

2002

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Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice

British journal of cancer, 2004-02, Vol.90 (4), p.906-910

2004

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Nucleolar damage correlates with neurotoxicity induced by different platinum drugs

British journal of cancer, 2001-10, Vol.85 (8), p.1219-1225

2001

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Cell cycle times of short-term cultures of brain cancers as predictors of survival

British journal of cancer, 2008-11, Vol.99 (10), p.1678-1683

2008

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Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

British journal of cancer, 2003-06, Vol.88 (12), p.1844-1850

2003

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Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2383-2393

1999

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The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor

European journal of cancer (1990), 2001-10, Vol.37 (15), p.1930-1937

2001

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Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2004-2014

2001

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Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

British journal of cancer, 1998-08, Vol.78 (4), p.439-445

1998

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In vitro modelling of human tumour behaviour in drug discovery programmes

European journal of cancer (1990), 2004-04, Vol.40 (6), p.794-801

2004

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From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives

European journal of cancer (1990), 1996-04, Vol.32 (4), p.708-714

1996

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Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in phase I clinical trial

Cancer chemotherapy and pharmacology, 2007-04, Vol.59 (5), p.681-687

2007

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Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1350-1358

2000

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Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice

Cancer research (Chicago, Ill.), 1999-07, Vol.59 (14), p.3304-3307

1999

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Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Bioorganic & medicinal chemistry, 2000-05, Vol.8 (5), p.977-984

2000

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Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity

British journal of cancer, 2003-06, Vol.88 (12), p.1942-1947

2003

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Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.2040-2046

1997

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Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid

British journal of cancer, 1999-05, Vol.80 (5-6), p.716-723

1999

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NF-kappa B activation in vivo in both host and tumour cells by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

European journal of cancer (1990), 2003-05, Vol.39 (8), p.1176-1183

2003

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Early stages of the apoptotic pathway in plant cells are reversible

The Plant journal : for cell and molecular biology, 1998-03, Vol.13 (6), p.803-814

1998

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Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity

British journal of cancer, 1998-08, Vol.78 (3), p.336-343

1998

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Stimulation of tumors to synthesize tumor necrosis factor-α in situ using 5,6-dimethylxanthenone-4-acetic acid : A novel approach to cancer therapy

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (3), p.633-638

1999

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Dicationic Bis(9-methylphenazine-1-carboxamides): Relationships between Biological Activity and Linker Chain Structure for a Series of Potent Topoisomerase Targeted Anticancer Drugs

Journal of medicinal chemistry, 2001-04, Vol.44 (9), p.1407-1415

2001

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Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: relation to vascular effects

Oncology research, 1997, Vol.9 (2), p.55

1997

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Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid

Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice

Nucleolar damage correlates with neurotoxicity induced by different platinum drugs

Cell cycle times of short-term cultures of brain cancers as predictors of survival

Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor

Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

In vitro modelling of human tumour behaviour in drug discovery programmes

From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives

Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in phase I clinical trial

Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice

Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity

Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid

NF-kappa B activation in vivo in both host and tumour cells by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Early stages of the apoptotic pathway in plant cells are reversible

Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity

Stimulation of tumors to synthesize tumor necrosis factor-α in situ using 5,6-dimethylxanthenone-4-acetic acid : A novel approach to cancer therapy

Dicationic Bis(9-methylphenazine-1-carboxamides): Relationships between Biological Activity and Linker Chain Structure for a Series of Potent Topoisomerase Targeted Anticancer Drugs

Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: relation to vascular effects

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