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One-pot palladium-catalyzed synthesis of sulfonyl fluorides from aryl bromides

Chemical science (Cambridge), 2017, Vol.8 (2), p.1233-1237

2017

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Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(II) carboxylates

Nature chemistry, 2022-01, Vol.14 (1), p.94-99

2022

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Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

Angewandte Chemie International Edition, 2019-12, Vol.58 (52), p.18859-18863

International ed. in English, 2019

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Application of Fundamental Organometallic Chemistry to the Development of a Gold-Catalyzed Synthesis of Sulfinate Derivatives

Angewandte Chemie International Edition, 2014-04, Vol.53 (17), p.4404-4407

International ed. in English, 2014

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A focus on computer vision for non-contact monitoring of catalyst degradation and product formation kinetics

Chemical science (Cambridge), 2023-10, Vol.14 (4), p.1994-1996

2023

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Synthesis of 2‑Arylpiperidines via Pd-Catalyzed Arylation of Aza-Achmatowicz Rearrangement Products with Arylboronic Acids

Organic letters, 2020-01, Vol.22 (2), p.458-463

2020

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor

Journal of medicinal chemistry, 2022-06, Vol.65 (12), p.8208-8226

2022

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Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors

Journal of organic chemistry, 2023-10, Vol.88 (19), p.13727-13740

2023

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Iron-mediated modular decarboxylative cross-nucleophile coupling

Chem, 2023-06, Vol.9 (6), p.1610-1621

2023

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6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor

Bioorganic & medicinal chemistry letters, 2023-10, Vol.94, p.129454-129454, Article 129454

2023

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Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Journal of medicinal chemistry, 2014-12, Vol.57 (24), p.10512-10526

2014

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10879-10896

2020

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Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3685-3696

2018

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2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.3114-3125

2018

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The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Journal of organic chemistry, 2016-05, Vol.81 (9), p.3509-3519

2016

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Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7110-7119

2013

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Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

Angewandte Chemie, 2019-12, Vol.131 (52), p.19035-19039

2019

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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5352-5356

2015

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Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-02, Vol.77 (3), p.1497-1506

2012

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Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

ACS medicinal chemistry letters, 2015-11, Vol.6 (11), p.1128-1133

2015

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Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7523-7529

2012

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Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo

Molecular pharmacology, 2009-02, Vol.75 (2), p.296-306

2009

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One-pot palladium-catalyzed synthesis of sulfonyl fluorides from aryl bromides

Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(II) carboxylates

Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

Application of Fundamental Organometallic Chemistry to the Development of a Gold-Catalyzed Synthesis of Sulfinate Derivatives

A focus on computer vision for non-contact monitoring of catalyst degradation and product formation kinetics

Synthesis of 2‑Arylpiperidines via Pd-Catalyzed Arylation of Aza-Achmatowicz Rearrangement Products with Arylboronic Acids

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor

Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors

Iron-mediated modular decarboxylative cross-nucleophile coupling

6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

Cyclic Alkenylsulfonyl Fluorides: Palladium‐Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo

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