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An Oxidation and Ring Contraction Approach to the Synthesis of (±)-1-Deoxynojirimycin and (±)-1-Deoxyaltronojirimycin

Organic letters, 2010-01, Vol.12 (1), p.136-139

2010

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Syntheses of the Enantiomers of 1-Deoxynojirimycin and 1-Deoxyaltronojirimycin via Chemo- and Diastereoselective Olefinic Oxidation of Unsaturated Amines

Journal of organic chemistry, 2010-12, Vol.75 (23), p.8133-8146

2010

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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.593-624

2013

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Recent progress in sodium channel modulators for pain

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3690-3699

2014

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Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation

Journal of chemical information and modeling, 2017-04, Vol.57 (4), p.897-909

2017

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Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer

Journal of medicinal chemistry, 2024-07, Vol.67 (14), p.11732-11750

2024

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The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10084-10099

2016

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17146-17183

2021

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Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6814-6826

2021

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Voltage gated sodium channels as drug discovery targets

Channels (Austin, Tex.), 2015-11, Vol.9 (6), p.360-366

2015

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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.247-265

2019

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Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4541-4559

2024

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Recent advances in biomimetic natural product synthesis

Natural product reports, 2008-01, Vol.25 (2), p.254-297

2008

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

Bioorganic & medicinal chemistry letters, 2021-05, Vol.39, p.127904-127904, Article 127904

2021

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.9147-9160

2023

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.9147-9160

2023

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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6779-6800

2018

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6940-6952

2022

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6940-6952

2022

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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

Bioorganic & medicinal chemistry, 2019-01, Vol.27 (1), p.230-239

2019

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Concise and highly selective asymmetric synthesis of acosamine from sorbic acid

Tetrahedron letters, 2011-04, Vol.52 (17), p.2216-2220

2011

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Minimizing Drug Exposure in the CNS while Maintaining Good Oral Absorption

ACS medicinal chemistry letters, 2012-12, Vol.3 (12), p.948-950

2012

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Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.650-654

2015

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An Oxidation and Ring Contraction Approach to the Synthesis of (±)-1-Deoxynojirimycin and (±)-1-Deoxyaltronojirimycin

Syntheses of the Enantiomers of 1-Deoxynojirimycin and 1-Deoxyaltronojirimycin via Chemo- and Diastereoselective Olefinic Oxidation of Unsaturated Amines

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Recent progress in sodium channel modulators for pain

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation

Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

Voltage gated sodium channels as drug discovery targets

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Development of a Series of Pyrrolopyridone MAT2A Inhibitors

Recent advances in biomimetic natural product synthesis

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS G12C

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C

Concise and highly selective asymmetric synthesis of acosamine from sorbic acid

Minimizing Drug Exposure in the CNS while Maintaining Good Oral Absorption

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

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