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Characterization of a novel glucokinase activator in rat and mouse models

PloS one, 2014-02, Vol.9 (2), p.e88431

2014

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CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism

Drug metabolism reviews, 2006-01, Vol.38 (3), p.451-476

2006

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The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation

The Journal of biological chemistry, 2017-03, Vol.292 (13), p.5610-5621

2017

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Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

Chemical research in toxicology, 2005-05, Vol.18 (5), p.855-864

2005

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Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2024-08, Vol.67 (15), p.13019-13032

2024

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Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Chemical research in toxicology, 2009-07, Vol.22 (7), p.1298-1309

2009

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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1230-1234

2018

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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115232-115232, Article 115232

2020

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Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation

Chemical research in toxicology, 2007-06, Vol.20 (6), p.954

2007

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Discovery of 2‑Pyridylureas as Glucokinase Activators

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8180-8186

2014

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Time-Dependent Inactivation of P450 3A4 by Raloxifene: Identification of Cys239 as the Site of Apoprotein Alkylation1

Chemical research in toxicology, 2007-06, Vol.20 (6), p.954-964

2007

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1284-1289

2014

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Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18O Protein Labeling Studies

Biochemistry (Easton), 2007-10, Vol.46 (41), p.11598-11605

2007

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Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group

Archives of biochemistry and biophysics, 2003-08, Vol.416 (1), p.17-24

2003

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Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate

Biochemistry (Easton), 2003-04, Vol.42 (15), p.4601-4606

2003

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Sites of Covalent Attachment of CYP4 Enzymes to Heme: Evidence for Microheterogeneity of P450 Heme Orientation

Biochemistry (Easton), 2005-10, Vol.44 (42), p.13914-13920

2005

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Abstract B23: Insight towards therapeutic susceptibility of KRAS mutant cancers from MRTX1257: A prototype selective inhibitor of KRAS G12C

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B23-B23

2020

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Abstract B30: Structure-based drug discovery of MRTX1257, a selective, covalent KRAS G12C inhibitor with oral activity in animal models of cancer

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B30-B30

2020

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Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: O-18 Protein Labeling Studies

Biochemistry (Easton), 2007-10, Vol.46 (41), p.11598-11605

2007

Volltextzugriff (PDF)

Benzylic Oxidation of Gemfibrozil-1-O-b-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Chemical research in toxicology, 2009-05, Vol.22 (7), p.1298-1309

2009

Volltextzugriff (PDF)

Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18 O Protein Labeling Studies

Biochemistry (Easton), 2007-10, Vol.46 (41), p.11598-11605

2007

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Characterization of a novel glucokinase activator in rat and mouse models

CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism

The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation

Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer

Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer

Discovery of 2‑Pyridylureas as Glucokinase Activators

Time-Dependent Inactivation of P450 3A4 by Raloxifene: Identification of Cys239 as the Site of Apoprotein Alkylation1

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18O Protein Labeling Studies

Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group

Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate

Sites of Covalent Attachment of CYP4 Enzymes to Heme: Evidence for Microheterogeneity of P450 Heme Orientation

Abstract B23: Insight towards therapeutic susceptibility of KRAS mutant cancers from MRTX1257: A prototype selective inhibitor of KRAS G12C

Abstract B30: Structure-based drug discovery of MRTX1257, a selective, covalent KRAS G12C inhibitor with oral activity in animal models of cancer

Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: O-18 Protein Labeling Studies

Benzylic Oxidation of Gemfibrozil-1-O-b-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18 O Protein Labeling Studies

The KRAS G12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

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