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Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

Nature medicine, 2013-09, Vol.19 (9), p.1111-1113

2013

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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Nature communications, 2018-06, Vol.9 (1), p.2491-9, Article 2491

2018

Volltextzugriff (PDF)

Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo

Nature communications, 2021-05, Vol.12 (1), p.3210-3210, Article 3210

2021

Volltextzugriff (PDF)

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

Molecular therapy, 2015-10, Vol.23 (10), p.1592-1599

2015

Volltextzugriff (PDF)

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

EMBO molecular medicine, 2018-09, Vol.10 (9), p.n/a

2018

Volltextzugriff (PDF)

Myopathy reversion in mice after restauration of mitochondrial complex I

EMBO molecular medicine, 2020-02, Vol.12 (2), p.e10674-n/a

2020

Volltextzugriff (PDF)

Manipulation of mitochondrial genes and mtDNA heteroplasmy

Methods in cell biology, 2020, Vol.155, p.441-487

2020

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Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Cell death and differentiation, 2017-02, Vol.24 (2), p.288-299

2017

Volltextzugriff (PDF)

The use of mitochondria-targeted endonucleases to manipulate mtDNA

Methods in enzymology, 2014, Vol.547, p.373-397

2014

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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Nature medicine, 2018-09, Vol.24 (11), p.1696-1700

2018

Volltextzugriff (PDF)

Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR

The Journal of biological chemistry, 2022-11, Vol.298 (11), p.102574, Article 102574

2022

Volltextzugriff (PDF)

Cybrid technology

Methods in cell biology, 2020, Vol.155, p.415-439

2020

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Mitochondrial Involvement in Amyotrophic Lateral Sclerosis: Trigger or Target?

Molecular neurobiology, 2006, Vol.33 (2), p.113-132

2006

Volltextzugriff (PDF)

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

Nucleic acids research, 2009-07, Vol.37 (13), p.4218

2009

Volltextzugriff (PDF)

mitoTALEN reduces the mutant mtDNA load in neurons

Molecular therapy. Nucleic acids, 2024-03, Vol.35 (1), p.102132, Article 102132

2024

Volltextzugriff (PDF)

Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease

Nature metabolism, 2023-12, Vol.5 (12), p.2169

2023

Volltextzugriff (PDF)

Manipulating mitochondrial genomes in the clinic: playing by different rules

Trends in cell biology, 2014-04, Vol.24 (4), p.209-211

2014

Volltextzugriff (PDF)

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Nature medicine, 2018-12, Vol.24 (12), p.1940-1940

2018

Volltextzugriff (PDF)

Cytochrome c Association with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice

The Journal of neuroscience, 2005-01, Vol.25 (1), p.164-172

2005

Volltextzugriff (PDF)

Emerging therapeutic approaches to mitochondrial diseases

Developmental disabilities research reviews, 2010-06, Vol.16 (2), p.219-229

2010

Volltextzugriff (PDF)

DNA‐editing enzymes as potential treatments for heteroplasmic mtDNA diseases

Journal of internal medicine, 2020-06, Vol.287 (6), p.685-697

2020

Volltextzugriff (PDF)

Human primary Sjögren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors

Current eye research, 1998, Vol.17 (12), p.1135-1142

1998

Volltextzugriff (PDF)

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease

Gene therapy, 2012-11, Vol.19 (11), p.1101-1106

2012

Volltextzugriff (PDF)

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

Gene therapy, 2010-06, Vol.17 (6), p.713-720

2010

Volltextzugriff (PDF)

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Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

Selective elimination of mitochondrial mutations in the germline by genome editing

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

Myopathy reversion in mice after restauration of mitochondrial complex I

Manipulation of mitochondrial genes and mtDNA heteroplasmy

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

The use of mitochondria-targeted endonucleases to manipulate mtDNA

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR

Cybrid technology

Mitochondrial Involvement in Amyotrophic Lateral Sclerosis: Trigger or Target?

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

mitoTALEN reduces the mutant mtDNA load in neurons

Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease

Manipulating mitochondrial genomes in the clinic: playing by different rules

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Cytochrome c Association with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice

Emerging therapeutic approaches to mitochondrial diseases

DNA‐editing enzymes as potential treatments for heteroplasmic mtDNA diseases

Human primary Sjögren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

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