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Human FGF-21 Is a Substrate of Fibroblast Activation Protein

PloS one, 2016-03, Vol.11 (3), p.e0151269

2016

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GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice

Diabetes (New York, N.Y.), 2015-07, Vol.64 (7), p.2409-2419

2015

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Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

The Journal of biological chemistry, 2016-04, Vol.291 (15), p.8070-8089

2016

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A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

Nature chemical biology, 2014-08, Vol.10 (8), p.656

2014

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Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma

Cancers, 2021-11, Vol.13 (21), p.5495

2021

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DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Nature chemical biology, 2017-01, Vol.13 (1), p.46

2017

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Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4365-4377

2011

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Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth

Molecular cancer therapeutics, 2005-03, Vol.4 (3), p.351-360

2005

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Design and synthesis of boronic acid inhibitors of endothelial lipase

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1397-1401

2012

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High-Frequency Dynamic Nuclear Polarization in MAS Spectra of Membrane and Soluble Proteins

Journal of the American Chemical Society, 2003-11, Vol.125 (45), p.13626-13627

2003

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Measurement of NH Bond Lengths by Fast Magic-Angle Spinning Solid-State NMR Spectroscopy: A New Method for the Quantification of Hydrogen Bonds

Journal of the American Chemical Society, 2001-11, Vol.123 (44), p.11097-11098

2001

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Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors

Journal of Nuclear Medicine, 2024, Vol.65 (1), p.100-108

2024

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A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment

Science (American Association for the Advancement of Science), 1997-11, Vol.278 (5340), p.1128-1132

1997

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Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

Journal of medicinal chemistry, 2013-05, Vol.56 (9), p.3467-3477

2013

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Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma

Peptides (New York, N.Y. : 1980), 2016-01, Vol.75, p.80-95

2016

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Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis

International journal of rheumatic diseases, 2018-11, Vol.21 (11), p.1915-1923

2018

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Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice

Molecular metabolism (Germany), 2019-01, Vol.19, p.65-74

2019

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A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8339-8351

2013

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α-Lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities

Proceedings of the National Academy of Sciences - PNAS, 2005-01, Vol.102 (4), p.1006-1011

2005

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A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Vaccine, 2014-05, Vol.32 (26), p.3223-3231

2014

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Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.6005-6013

2008

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A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy

Journal of immunotherapy (1997), 2013-10, Vol.36 (8), p.400

2013

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Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice

Journal of cardiovascular pharmacology and therapeutics, 2012-09, Vol.17 (3), p.334-343

2012

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Pro-Soft Val-boroPro: A Strategy for Enhancing in Vivo Performance of Boronic Acid Inhibitors of Serine Proteases

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2022-2028

2011

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Human FGF-21 Is a Substrate of Fibroblast Activation Protein

GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors

Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth

Design and synthesis of boronic acid inhibitors of endothelial lipase

High-Frequency Dynamic Nuclear Polarization in MAS Spectra of Membrane and Soluble Proteins

Measurement of NH Bond Lengths by Fast Magic-Angle Spinning Solid-State NMR Spectroscopy: A New Method for the Quantification of Hydrogen Bonds

Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-α (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors

A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment

Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma

Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis

Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs

A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates

α-Lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety

A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy

Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice

Pro-Soft Val-boroPro: A Strategy for Enhancing in Vivo Performance of Boronic Acid Inhibitors of Serine Proteases

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