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Polyamine synthesis as a target of MYC oncogenes

The Journal of biological chemistry, 2018-11, Vol.293 (48), p.18757-18769

2018

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plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Nature, 2008-04, Vol.452 (7188), p.755-758

2008

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Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

Journal of natural products (Washington, D.C.), 2020-08, Vol.83 (8), p.2518-2527

2020

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Anti-tumor effect of sulfasalazine in neuroblastoma

Biochemical pharmacology, 2019-04, Vol.162, p.237-249

2019

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AMXT‐1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

International journal of cancer, 2013-09, Vol.133 (6), p.1323-1333

2013

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Bachmann–Bupp syndrome and treatment

Developmental medicine and child neurology, 2024-04, Vol.66 (4), p.445-455

2024

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Ornithine decarboxylase as a therapeutic target for endometrial cancer

PloS one, 2017-12, Vol.12 (12), p.e0189044-e0189044

2017

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Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation

Biochemical journal, 2019-07, Vol.476 (14), p.2047-2057

2019

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Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma

Cancer chemotherapy and pharmacology, 2021-10, Vol.88 (4), p.607-617

2021

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Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Cancer cell international, 2018-06, Vol.18 (1), p.82-82, Article 82

2018

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Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer

Journal of drug targeting, 2022-07, Vol.30 (6), p.623-633

2022

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Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features

American journal of medical genetics. Part A, 2018-12, Vol.176 (12), p.2548-2553

2018

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Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

eLife, 2021-07, Vol.10

2021

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Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma

European journal of medicinal chemistry, 2022-12, Vol.244, p.114818-114818, Article 114818

2022

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Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (16), p.6507-6512

2009

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Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo

Leukemia research, 2020-01, Vol.88, p.106271-106271, Article 106271

2020

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Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation

Journal of molecular biology, 2014-01, Vol.426 (2), p.332-346

2014

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Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

BMC cancer, 2015-06, Vol.15 (1), p.477-477, Article 477

2015

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Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit

EBioMedicine, 2020-12, Vol.62, p.103122, Article 103122

2020

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Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation

RSC advances, 2021-10, Vol.11 (53), p.3326-3327

2021

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New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

Biology open, 2023-03, Vol.12 (3)

2023

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Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death

The Journal of biological chemistry, 2016-04, Vol.291 (16), p.8350-8362

2016

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Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors

European Journal of Organic Chemistry, 2010-07, Vol.2010 (21), p.3991-4003

2010

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Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development

Genes, 2021-03, Vol.12 (4), p.470

2021

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Polyamine synthesis as a target of MYC oncogenes

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells

Anti-tumor effect of sulfasalazine in neuroblastoma

AMXT‐1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

Bachmann–Bupp syndrome and treatment

Ornithine decarboxylase as a therapeutic target for endometrial cancer

Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation

Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer

Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features

Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo

Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation

Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit

Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation

New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

Syrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death

Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors

Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development

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