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Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

Science (American Association for the Advancement of Science), 1997-06, Vol.276 (5319), p.1696-1699

1997

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5-Ethynyluracil (776C85): A Potent Modulator of the Pharmacokinetics and Antitumor Efficacy of 5-Fluorouracil

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.11064-11068

1993

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X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH Is Displaced by an Inhibitor

Journal of medicinal chemistry, 2001-08, Vol.44 (18), p.2928-2932

2001

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α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

Biochemical pharmacology, 2000-04, Vol.59 (8), p.953-960

2000

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5-Ethynyluracil (77C85) : effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil

Cancer research (Chicago, Ill.), 1995-12, Vol.55 (24), p.6227-6230

1995

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Basis of Selectivity of Antibacterial Diaminopyrimidines

Journal of chemotherapy, 1993-12, Vol.5 (6), p.393-399

1993

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Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics : allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

Cancer chemotherapy and pharmacology, 1997, Vol.39 (3), p.233-238

1997

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Inhibition of Uridine Phosphorylase. Synthesis and Structure−Activity Relationships of Aryl-Substituted 1-((2-Hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil

Journal of medicinal chemistry, 1997-04, Vol.40 (8), p.1179-1185

1997

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5-Ethynyluracil (776C85): Protection from 5-fluorouracil-induced neurotoxicity in dogs

Biochemical pharmacology, 1994-07, Vol.48 (2), p.233-236

1994

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Characterization of Candida albicans Dihydrofolate Reductase

The Journal of biological chemistry, 1989-01, Vol.264 (2), p.1100-1107

1989

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Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3850-3856

1995

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High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with Small Molecular Size

Journal of medicinal chemistry, 1996-02, Vol.39 (4), p.892-903

1996

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Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67

Biochemistry (Easton), 1986-07, Vol.25 (15), p.4194-4204

1986

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X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex

The Journal of biological chemistry, 1997-11, Vol.272 (48), p.30289-30298

1997

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Selective Inhibitors of Candida albicans Dihydrofolate Reductase: Activity and Selectivity of 5-(Arylthio)-2,4-diaminoquinazolines

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3608-3616

1995

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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogs with high activity and specificity for bacterial dihydrofolate reductase

Journal of medicinal chemistry, 1989-08, Vol.32 (8), p.1942-1949

1989

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Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding

The Journal of biological chemistry, 1981-02, Vol.256 (4), p.1738-1747

1981

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Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine

Biochemical pharmacology, 1993-01, Vol.45 (1), p.173-181

1993

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Characterization of an R-plasmid dihydrofolate reductase with a monomeric structure

The Journal of biological chemistry, 1984-05, Vol.259 (9), p.5851-5856

1984

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Peptide agonists of the thrombopoietin receptor

Stem cells (Dayton, Ohio), 1998, Vol.16 (S1), p.21-29

1998

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Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Bioorganic & medicinal chemistry, 1996-04, Vol.4 (4), p.593-602

1996

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Refolding of Recombinant Pneumocystis carinii Dihydrofolate Reductase and Characterization of the Enzyme

Protein expression and purification, 1993-02, Vol.4 (1), p.16-23

1993

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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.122-129

1988

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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Journal of medicinal chemistry, 1985-03, Vol.28 (3), p.303-311

1985

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Characterization and amino acid sequence of Neisseria gonorrhoeae dihydrofolate reductase

The Journal of biological chemistry, 1984-10, Vol.259 (19), p.12291-12298

1984

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Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

5-Ethynyluracil (776C85): A Potent Modulator of the Pharmacokinetics and Antitumor Efficacy of 5-Fluorouracil

X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH Is Displaced by an Inhibitor

α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil

5-Ethynyluracil (77C85) : effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil

Basis of Selectivity of Antibacterial Diaminopyrimidines

Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics : allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

Inhibition of Uridine Phosphorylase. Synthesis and Structure−Activity Relationships of Aryl-Substituted 1-((2-Hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil

5-Ethynyluracil (776C85): Protection from 5-fluorouracil-induced neurotoxicity in dogs

Characterization of Candida albicans Dihydrofolate Reductase

Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils

High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with Small Molecular Size

Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67

X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex

Selective Inhibitors of Candida albicans Dihydrofolate Reductase: Activity and Selectivity of 5-(Arylthio)-2,4-diaminoquinazolines

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogs with high activity and specificity for bacterial dihydrofolate reductase

Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding

Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine

Characterization of an R-plasmid dihydrofolate reductase with a monomeric structure

Peptide agonists of the thrombopoietin receptor

Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim

Refolding of Recombinant Pneumocystis carinii Dihydrofolate Reductase and Characterization of the Enzyme

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Characterization and amino acid sequence of Neisseria gonorrhoeae dihydrofolate reductase

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