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Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice

Antiviral research, 2012-04, Vol.94 (1), p.103-110

2012

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Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme

Antiviral research, 2011-09, Vol.91 (3), p.288-291

2011

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Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice

Antiviral research, 2010-10, Vol.88 (1), p.38-44

2010

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Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model

Antiviral research, 2010-12, Vol.88 (3), p.276-280

2010

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An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral

Antiviral research, 2021-11, Vol.195, p.105180-105180, Article 105180

2021

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Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

Antimicrobial Agents and Chemotherapy, 2001-04, Vol.45 (4), p.1162-1167

2001

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A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice

Antiviral research, 2011-04, Vol.90 (1), p.17-21

2011

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Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

Antiviral research, 2017-01, Vol.137, p.14-22

2017

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BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

Journal of medicinal chemistry, 2000-09, Vol.43 (19), p.3482-3486

2000

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Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases

European journal of medicinal chemistry, 2024-01, Vol.264, p.115991-115991, Article 115991

2024

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Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors

Bioorganic & medicinal chemistry, 2022-11, Vol.74, p.117034-117034, Article 117034

2022

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Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15907-15915

2017

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Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon

Bioorganic & medicinal chemistry, 2022-11, Vol.73, p.117035-117035, Article 117035

2022

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Systematic Structure-Based Design and Stereoselective Synthesis of Novel Multisubstituted Cyclopentane Derivatives with Potent Antiinfluenza Activity

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4379-4392

2001

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In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201

Antimicrobial Agents and Chemotherapy, 2001-03, Vol.45 (3), p.749-757

2001

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Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study

Allergy (Copenhagen), 2016-12, Vol.71 (12), p.1676-1683

2016

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Effectiveness of the Guidelines for the Non-Operative Management of Knee Osteoarthritis

Archives of bone and joint surgery, 2021-07, Vol.9 (4), p.472-474

2021

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Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2′-deoxyguanosine in primates

International immunopharmacology, 2003-04, Vol.3 (4), p.541-548

2003

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Need for Appropriate Hospital Attire in Orthopedic Patients

Apollo medicine, 2021-06, Vol.18 (2), p.93-98

2021

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Three-dimensional Structure of Influenza A N9 Neuraminidase and Its Complex with the Inhibitor 2-Deoxy 2,3-Dehydro- N-Acetyl Neuraminic Acid

Journal of molecular biology, 1993, Vol.232 (4), p.1069-1083

1993

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Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design

Journal of medicinal chemistry, 1997-12, Vol.40 (25), p.4030-4052

1997

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Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2332-2343

1999

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Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201

Antiviral research, 2001-09, Vol.51 (3), p.179-187

2001

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Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Bioorganic & medicinal chemistry, 1999-11, Vol.7 (11), p.2487-2497

1999

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Efficacy of Novel Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 against Human Parainfluenza Viruses In Vitro and In Vivo

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1495-1502

2004

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Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice

Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme

Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice

Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model

An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral

Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice

Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design

Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases

Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors

Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase

Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon

Systematic Structure-Based Design and Stereoselective Synthesis of Novel Multisubstituted Cyclopentane Derivatives with Potent Antiinfluenza Activity

In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201

Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study

Effectiveness of the Guidelines for the Non-Operative Management of Knee Osteoarthritis

Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2′-deoxyguanosine in primates

Need for Appropriate Hospital Attire in Orthopedic Patients

Three-dimensional Structure of Influenza A N9 Neuraminidase and Its Complex with the Inhibitor 2-Deoxy 2,3-Dehydro- N-Acetyl Neuraminic Acid

Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design

Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent

Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

Efficacy of Novel Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 against Human Parainfluenza Viruses In Vitro and In Vivo

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