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Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma

BBA clinical, 2016-12, Vol.6, p.49-68

Babizhayev, Mark A.

2016

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Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products

Life sciences (1973), 2006-04, Vol.78 (20), p.2343-2357

Babizhayev, Mark A.

2006

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The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients

Cell biochemistry and biophysics, 2015-04, Vol.71 (3), p.1425-1443

2015

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Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration

Fundamental & clinical pharmacology, 2011-08, Vol.25 (4), p.425-442

2011

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Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities

Current pharmaceutical biotechnology, 2014-01, Vol.15 (8), p.738-778

Babizhayev, Mark A

2014

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Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy

Frontiers in bioscience, 2010-06, Vol.15 (3), p.934

2010

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Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals

Current drug delivery, 2014-02, Vol.11 (1), p.24-61

2014

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Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous

Fundamental & clinical pharmacology, 2011-04, Vol.25 (2), p.139-162

2011

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Reactive Oxygen Species and the Aging Eye: Specific Role of Metabolically Active Mitochondria in Maintaining Lens Function and in the Initiation of the Oxidation-Induced Maturity Onset Cataract--A Novel Platform of Mitochondria-Targeted Antioxidants With Broad Therapeutic Potential for Redox Regulation and Detoxification of Oxidants in Eye Diseases

American journal of therapeutics, 2016-01, Vol.23 (1), p.e98-e117

2016

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Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production

American journal of therapeutics, 2012-01, Vol.19 (1), p.e25-e47

2012

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Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine

Fundamental & clinical pharmacology, 2012-02, Vol.26 (1), p.86-117

Babizhayev, Mark A.

2012

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Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease

Cell biochemistry and function, 2011-04, Vol.29 (3), p.183-206

Babizhayev, Mark A.

2011

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N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population

Clinical interventions in aging, 2009-01, Vol.4, p.31-50

2009

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Cataract halos: A driving hazard in aging populations. Implication of the Halometer DG test for assessment of intraocular light scatter

Applied ergonomics, 2009-05, Vol.40 (3), p.545-553

2009

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Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies

Journal of biomedical materials research. Part A, 2015-12, Vol.103 (12), p.3993-4023

2015

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Patenting strategies, the authentication US fiscal methodology, discovery and development of imidazole-containing peptide compounds with free-radical scavenging and transglycating properties acting as targeted drug regulators and homeostatic agents with diverse therapeutic activities for pharmacy of diabetes and metabolic diseases

Expert opinion on therapeutic patents, 2015-09, Vol.25 (11), p.1319-21

Babizhayev, Mark A

2015

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The detox strategy in smoking comprising nutraceutical formulas of non-hydrolyzed carnosine or carcinine used to protect human health

Human & experimental toxicology, 2014-03, Vol.33 (3), p.284-316

Babizhayev, Mark A

2014

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Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior

American journal of therapeutics, 2011-11, Vol.18 (6), p.e209-e226

2011

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Designation of imidazole-containing dipeptides as pharmacological chaperones

Human & experimental toxicology, 2011-07, Vol.30 (7), p.736-761

Babizhayev, Mark A

2011

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New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans

American journal of therapeutics, 2010-07, Vol.17 (4), p.373-389

Babizhayev, Mark A

2010

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Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina

Investigative ophthalmology & visual science, 2012-06, Vol.53 (7), p.3572-3583

2012

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Ocular Drug Metabolism of the Bioactivating Antioxidant N-acetylcarnosine for Vision in Ophthalmic Prodrug and Codrug Design and Delivery

Drug development and industrial pharmacy, 2008-01, Vol.34 (10), p.1071-1089

Babizhayev, Mark A.

2008

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Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform

Drug testing and analysis, 2012-06, Vol.4 (6), p.468-485

Babizhayev, Mark A.

2012

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N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications

Journal of drug targeting, 2009, Vol.17 (1), p.36-63

2009

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N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients

American journal of therapeutics, 2009-11, Vol.16 (6), p.517-533

2009

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Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma

Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products

The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients

Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration

Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy

Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous

Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production

Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease

N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population

Cataract halos: A driving hazard in aging populations. Implication of the Halometer DG test for assessment of intraocular light scatter

Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies

The detox strategy in smoking comprising nutraceutical formulas of non-hydrolyzed carnosine or carcinine used to protect human health

Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior

Designation of imidazole-containing dipeptides as pharmacological chaperones

Carcinine has 4-hydroxynonenal scavenging property and neuroprotective effect in mouse retina

Ocular Drug Metabolism of the Bioactivating Antioxidant N-acetylcarnosine for Vision in Ophthalmic Prodrug and Codrug Design and Delivery

Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform

N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications

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