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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility

Bioorganic & medicinal chemistry, 2012-09, Vol.20 (18), p.5507-5517

2012

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Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors

Bioorganic & medicinal chemistry, 2012-09, Vol.20 (18), p.5496-5506

2012

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Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists

Bioorganic & medicinal chemistry, 2012-04, Vol.20 (7), p.2338-2352

2012

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Discovery and characterization of novel allosteric FAK inhibitors

European journal of medicinal chemistry, 2013-03, Vol.61, p.49-60

2013

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Structure-based discovery of cellular-active allosteric inhibitors of FAK

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (6), p.1779-1785

2013

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Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists

Bioorganic & medicinal chemistry, 2013-01, Vol.21 (1), p.70-83

2013

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Synthesis and evaluation of hedgehog signaling inhibitor with novel core system

Bioorganic & medicinal chemistry, 2015-08, Vol.23 (15), p.4777-4791

2015

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Synthesis and structure–activity relationship of tetrahydropyrazolopyrimidine derivatives—A novel structural class of potent calcium-sensing receptor antagonists

Bioorganic & medicinal chemistry, 2010-12, Vol.18 (24), p.8501-8511

2010

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Synthesis and structure–activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (11), p.3841-3859

2010

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2-Acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (14), p.5157-5171

2010

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Discovery of Novel and Potent Orally Active Calcium-Sensing Receptor Antagonists that Stimulate Pulselike Parathyroid Hormone Secretion: Synthesis and Structure−Activity Relationships of Tetrahydropyrazolopyrimidine Derivatives

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1430-1440

2011

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Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2, 3-b : 5, 4-c']dipyridine Derivatives and Their Anti-inflammatory Effect

Chemical and Pharmaceutical Bulletin, 1999/07/15, Vol.47(7), pp.993-999

1999

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Studies on Disease-Modifying Antirheumatic Drugs. III. Bone Resorption Inhibitory Effects of Ethyl 4-(3, 4-Dimethoxyphenyl)-6, 7-dimethoxy-2-(1, 2, 4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds

Chemical and Pharmaceutical Bulletin, 1999/03/15, Vol.47(3), pp.369-374

1999

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Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

Bioorganic & medicinal chemistry, 2011-03, Vol.19 (6), p.1881-1894

2011

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Studies on Disease-Modifying Antirheumatic Drugs. II. Synthesis and Activity of the Metabolites of Ethyl 4-(3, 4-Dimethoxyphenyl)-6, 7-dimethoxy-2-(1, 2, 4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603)

Chemical and Pharmaceutical Bulletin, 1998/07/15, Vol.46(7), pp.1130-1134

1998

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Studies on Disease-Modifying Antirheumatic Drugs: Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect

Journal of medicinal chemistry, 1996-12, Vol.39 (26), p.5176-5182

1996

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Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenyl-pyridine derivatives as novel antagonists of GPR54

Bioorganic & medicinal chemistry, 2010, Vol.18 (11), p.3841-3859

2010

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Total synthesis of (±)-helminthosporal via fragmentation reaction

Tetrahedron letters, 1991-11, Vol.32 (46), p.6741-6744

1991

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Immunomodulating and articular protecting activities of a new anti-rheumatic drug, TAK-603

Immunopharmacology, 1996-08, Vol.34 (1), p.17-26

1996

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Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2, 3-b

Chemical & pharmaceutical bulletin, 1999-07, Vol.47 (7), p.993

1999

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ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs. Part 4. Synthesis of Novel Thieno[2,3-b:5,4-c′]dipyridine Derivatives and Their Antiinflammatory Effect

ChemInform, 1999-11, Vol.30 (48), p.no-no

1999

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ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs. Part 3. Bone Resorption Inhibitory Effects of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2- (1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds

ChemInform, 1999-10, Vol.30 (42), p.no-no

1999

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Acrosin is essential for sperm penetration through the zona pellucida in hamsters

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (5), p.2513-2518

2020

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Elite competitive swimmers exhibit higher motor cortical inhibition and superior sensorimotor skills in a water environment

Behavioural brain research, 2020-10, Vol.395, p.112835-112835, Article 112835

2020

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Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning

Chemical communications (Cambridge, England), 2022-05, Vol.58 (44), p.6377-638

2022

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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors

Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists

Discovery and characterization of novel allosteric FAK inhibitors

Structure-based discovery of cellular-active allosteric inhibitors of FAK

Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system

Synthesis and structure–activity relationship of tetrahydropyrazolopyrimidine derivatives—A novel structural class of potent calcium-sensing receptor antagonists

Synthesis and structure–activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54

2-Acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats

Discovery of Novel and Potent Orally Active Calcium-Sensing Receptor Antagonists that Stimulate Pulselike Parathyroid Hormone Secretion: Synthesis and Structure−Activity Relationships of Tetrahydropyrazolopyrimidine Derivatives

Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2, 3-b : 5, 4-c']dipyridine Derivatives and Their Anti-inflammatory Effect

Studies on Disease-Modifying Antirheumatic Drugs. III. Bone Resorption Inhibitory Effects of Ethyl 4-(3, 4-Dimethoxyphenyl)-6, 7-dimethoxy-2-(1, 2, 4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds

Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent

Studies on Disease-Modifying Antirheumatic Drugs. II. Synthesis and Activity of the Metabolites of Ethyl 4-(3, 4-Dimethoxyphenyl)-6, 7-dimethoxy-2-(1, 2, 4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603)

Studies on Disease-Modifying Antirheumatic Drugs: Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect

Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenyl-pyridine derivatives as novel antagonists of GPR54

Total synthesis of (±)-helminthosporal via fragmentation reaction

Immunomodulating and articular protecting activities of a new anti-rheumatic drug, TAK-603

Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2, 3-b

ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs. Part 4. Synthesis of Novel Thieno[2,3-b:5,4-c′]dipyridine Derivatives and Their Antiinflammatory Effect

ChemInform Abstract: Studies on Disease-Modifying Antirheumatic Drugs. Part 3. Bone Resorption Inhibitory Effects of Ethyl 4-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-2- (1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and Related Compounds

Acrosin is essential for sperm penetration through the zona pellucida in hamsters

Elite competitive swimmers exhibit higher motor cortical inhibition and superior sensorimotor skills in a water environment

Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning

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