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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2452-2455
2010
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Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation
The Journal of biological chemistry, 2008-08, Vol.283 (35), p.23721-23730
2008
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Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2:  A Structural Basis for the Reduction of Albumin Binding
Journal of medicinal chemistry, 2006-06, Vol.49 (13), p.3832-3849
2006
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Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3574-3577
2006
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Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases
Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1718-1721
2009
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Pyrazolo[3,4- d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR)
Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5406-5409
2007
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3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.865-868
2004
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Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2
Cancer research (Chicago, Ill.), 2003-11, Vol.63 (22), p.7861-7869
2003
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3,5-Bis(trifluoromethyl)pyrazoles:  A Novel Class of NFAT Transcription Factor Regulator
Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.2975-2981
2000
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Abstract A245: Imidazo[2,1-b]thiazole and imidazo[1,2-a]pyridine amides as novel inhibitors of the insulin-like growth factor (IGF1R) and members of the epidermal growth factor family of tyrosine kinases
Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.A245-A245
2009
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Rapamycin analogs with reduced systemic exposure
Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5340-5343
2005
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Amide proton exchange rates of a bound pepsin inhibitor determined by isotope-edited proton NMR experiments
Biochemical and biophysical research communications, 1987-09, Vol.147 (3), p.892-898
1987
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Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases
Current pharmaceutical design, 1998-10, Vol.4 (5), p.367
1998
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A convenient stereoselective synthesis of 1,2,3-aminodiols from .alpha.-amino acids
Journal of organic chemistry, 1988-12, Vol.53 (26), p.6109-6112
1988
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Renin inhibitors. Dipeptide analogs of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency
Journal of medicinal chemistry, 1988-12, Vol.31 (12), p.2264-2276
1988
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New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site
Journal of medicinal chemistry, 1988-03, Vol.31 (3), p.532-539
1988
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New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P sub(1) site
Journal of medicinal chemistry, 1988-01, Vol.31 (3), p.532-539
1988
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