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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Journal of the American Chemical Society, 2010-12, Vol.132 (47), p.16962-16976

2010

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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Journal of organic chemistry, 2012-09, Vol.77 (17), p.7187-7211

2012

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Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer

Cancer research (Chicago, Ill.), 2017-03, Vol.77 (5), p.1200-1211

2017

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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5801-5804

2014

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Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization

ACS combinatorial science, 2012-02, Vol.14 (2), p.89-96

2012

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Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (19), p.5569-5580

2005

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Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides

Journal of organic chemistry, 2013-06, Vol.78 (11), p.5160-5171

2013

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Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis

ACS medicinal chemistry letters, 2011-09, Vol.2 (9), p.698-702

2011

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Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation

Chemistry & biology, 2013-05, Vol.20 (5), p.713-725

2013

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Vitamin D side chain triazole analogs via cycloaddition `click' chemistry

Tetrahedron letters, 2004-06, Vol.45 (24), p.4623-4625

2004

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Low-Calcemic, Highly Antiproliferative, 1-Difluoromethyl Hybrid Analogs of the Natural Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7513-7517

2006

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Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α, 25-dihydroxyvitamin D3

Journal of steroid biochemistry and molecular biology, 2004-05, Vol.89-90 (1-5), p.5-12

2004

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Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

Journal of steroid biochemistry and molecular biology, 2007-03, Vol.103 (3-5), p.213-221

2007

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Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2355-2358

2003

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P3.02b-119 YH25448, a Highly Selective 3rd Generation EGFR TKI, Exhibits Superior Survival over Osimertinib in Animal Model with Brain Metastases from NSCLC

Journal of thoracic oncology, 2017-01, Vol.12 (1), p.S1265-S1266

2017

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P3.02b-119 YH25448, a Highly Selective 3rd Generation EGFR TKI, Exhibits Superior Survival over Osimertinib in Animal Model with Brain Metastases from NSCLC: Topic: EGFR RES

Journal of thoracic oncology, 2017-01, Vol.12 (1), p.S1265-S1266

2017

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A formal synthesis of (+)-brefeldin A

Tetrahedron letters, 1998-07, Vol.39 (30), p.5377-5380

1998

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Low-Calcemic, Highly Antiproliferative, 1-Difluoromethyl Hybrid Analogs of the Natural Hormone 1α,25-Dihydroxyvitamin D 3 : Design, Synthesis, and Preliminary Biological Evaluation

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7513-7517

2006

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Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7513-7517

2006

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Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D 3

The Journal of steroid biochemistry and molecular biology, 2004-05, Vol.89, p.5-12

2004

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Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

The Journal of steroid biochemistry and molecular biology, 2007-03, Vol.103 (3-5), p.213-221

2007

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Difluoromethyl Analogs of the Natural Hormone 1a,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation

The Journal of steroid biochemistry and molecular biology, 2007-01, Vol.103 (3-5), p.213-221

2007

Volltextzugriff (PDF)

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D 3

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (19), p.5569-5580

2005

Volltextzugriff (PDF)

Vitamin D Side Chain Triazole Analogues via Cycloaddition ′Click′ Chemistry

ChemInform, 2004-09, Vol.35 (38), p.no-no

2004

Volltextzugriff (PDF)

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3

Bioorganic & medicinal chemistry, 2005-10, Vol.13 (19), p.5569-5580

2005

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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)

Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3

Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides

Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis

Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation

Vitamin D side chain triazole analogs via cycloaddition `click' chemistry

Low-Calcemic, Highly Antiproliferative, 1-Difluoromethyl Hybrid Analogs of the Natural Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α, 25-dihydroxyvitamin D3

Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics

P3.02b-119 YH25448, a Highly Selective 3rd Generation EGFR TKI, Exhibits Superior Survival over Osimertinib in Animal Model with Brain Metastases from NSCLC

P3.02b-119 YH25448, a Highly Selective 3rd Generation EGFR TKI, Exhibits Superior Survival over Osimertinib in Animal Model with Brain Metastases from NSCLC: Topic: EGFR RES

A formal synthesis of (+)-brefeldin A

Low-Calcemic, Highly Antiproliferative, 1-Difluoromethyl Hybrid Analogs of the Natural Hormone 1α,25-Dihydroxyvitamin D 3 : Design, Synthesis, and Preliminary Biological Evaluation

Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D 3

Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

Difluoromethyl Analogs of the Natural Hormone 1a,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D 3

Vitamin D Side Chain Triazole Analogues via Cycloaddition ′Click′ Chemistry

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3

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