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A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.12087-12095

2010

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Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

Antimicrobial Agents and Chemotherapy, 2011-03, Vol.55 (3), p.1088-1096

2011

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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (46), p.16274-16279

2014

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Candida albicans Pmr1p, a Secretory Pathway P-type Ca2+/Mn2+-ATPase, Is Required for Glycosylation and Virulence

The Journal of biological chemistry, 2005-06, Vol.280 (24), p.23408-23415

2005

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Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection

mBio, 2016-03, Vol.7 (2), p.e00225-e00225

2016

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Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae

Journal of Bacteriology, 2012-10, Vol.194 (20), p.5504-5512

2012

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A Novel Hexavalent Capsular Polysaccharide Conjugate Vaccine (GBS6) for the Prevention of Neonatal Group B Streptococcal Infections by Maternal Immunization

The Journal of infectious diseases, 2019-06, Vol.220 (1), p.105-115

2019

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Translating slow-binding inhibition kinetics into cellular and in vivo effects

Nature chemical biology, 2015-06, Vol.11 (6), p.416-423

2015

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Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37‑N 1)‑Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7788-7805

2019

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Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7019-7023

2012

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Multiple Paths for Nonphysiological Transport of K+ in Escherichia coli

Journal of Bacteriology, 2004-07, Vol.186 (13), p.4238-4245

2004

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Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

The Journal of clinical investigation, 2006-06, Vol.116 (6), p.1642-1650

2006

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Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2016-07, Vol.113 (29), p.8188-8193

2016

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Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (13), p.7670-7675

1998

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X‑ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.3156-3171

2015

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Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2532-2537

2012

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Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites

G3 : genes - genomes - genetics, 2015-10, Vol.5 (12), p.2555-2557

2015

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Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7278-7288

2013

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The CARB‑X Portfolio of Nontraditional Antibacterial Products

ACS infectious diseases, 2021-08, Vol.7 (8), p.2043-2049

2021

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Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.385-387

2006

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Selective Inhibitors of Bacterial t‑RNA-(N1G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7278-7288

2013

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The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

The Journal of biological chemistry, 2014-08, Vol.289 (31), p.21651-21662

2014

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In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae

The Journal of biological chemistry, 2011-11, Vol.286 (47), p.40734-40742

2011

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Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase

Antimicrobial Agents and Chemotherapy, 2004-01, Vol.48 (1), p.313-318

2004

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A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Candida albicans Pmr1p, a Secretory Pathway P-type Ca2+/Mn2+-ATPase, Is Required for Glycosylation and Virulence

Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection

Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae

A Novel Hexavalent Capsular Polysaccharide Conjugate Vaccine (GBS6) for the Prevention of Neonatal Group B Streptococcal Infections by Maternal Immunization

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37‑N 1)‑Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides

Vaccine value profile for Klebsiella pneumoniae

Multiple Paths for Nonphysiological Transport of K+ in Escherichia coli

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans

X‑ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein

Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery

Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain

The CARB‑X Portfolio of Nontraditional Antibacterial Products

Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

Selective Inhibitors of Bacterial t‑RNA-(N1G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain

The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae

Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase

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