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Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission

Nature communications, 2021-10, Vol.12 (1), p.6208-16, Article 6208

2021

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Adaptive Downregulation of Mitochondrial Function in Down Syndrome

Cell metabolism, 2013-01, Vol.17 (1), p.132-140

2013

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A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome

PloS one, 2010-12, Vol.5 (12), p.e14200-e14200

2010

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Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Free radical biology & medicine, 2008-06, Vol.44 (12), p.2051-2057

2008

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Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Aging cell, 2018-10, Vol.17 (5), p.e12812-n/a

2018

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Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (11), p.4315-4320

2013

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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

Cell reports (Cambridge), 2019-11, Vol.29 (8), p.2473-2488.e5

2019

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Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity

Frontiers in neurology, 2023-01, Vol.13, p.882635-882635

2023

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Altered zinc neuromodulation induces neuronal hyperactivity and cognitive impairment

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P634-P634

2015

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Low Cost Electrode Assembly for EEG Recordings in Mice

Frontiers in neuroscience, 2017-11, Vol.11, p.629-629

2017

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Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

The Journal of neuroscience, 2003-06, Vol.23 (11), p.4499-4508

2003

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Disruption of zinc neuromodulation by Aß oligomers: therapeutic implications

Current pharmaceutical design, 2014, Vol.20 (15), p.2520

2014

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Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia

Current Gerontology and Geriatrics Research, 2012, Vol.2012, p.383170-7

2012

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Beta-amyloid, oxidative stress and down syndrome

Current Alzheimer research, 2006-12, Vol.3 (5), p.521

2006

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Nature (London), 1995-12, Vol.378 (6559), p.776-779

1995

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ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

The Journal of neuroscience, 2005-03, Vol.25 (9), p.2295-2303

2005

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NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis

Current pharmaceutical design, 2007-04, Vol.13 (11), p.1091

2007

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Different Conformations of Amyloid beta Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

The Journal of neuroscience, 2006-05, Vol.26 (22), p.6011-6018

2006

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Mitochondrial dysfunction and Down's syndrome: Is there a role for coenzyme Q 10 ?

BioFactors (Oxford), 2011-09, Vol.37 (5), p.386-392

2011

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Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?

BioFactors (Oxford), 2011-09, Vol.37 (5), p.386-392

2011

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A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

The Journal of neuroscience, 2009-04, Vol.29 (13), p.4004-4015

2009

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Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome

Free radical biology & medicine, 2018-01, Vol.114, p.10-14

2018

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Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

Brain (London, England : 1878), 2020-12, Vol.143 (12), p.3653-3671

2020

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Methodological variables in the assessment of beta amyloid neurotoxicity

Neurobiology of aging, 1992-09, Vol.13 (5), p.609-612

1992

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Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter

Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity

Altered zinc neuromodulation induces neuronal hyperactivity and cognitive impairment

Low Cost Electrode Assembly for EEG Recordings in Mice

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

Disruption of zinc neuromodulation by Aß oligomers: therapeutic implications

Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Beta-amyloid, oxidative stress and down syndrome

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis

Different Conformations of Amyloid beta Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

Mitochondrial dysfunction and Down's syndrome: Is there a role for coenzyme Q 10 ?

Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?

A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

Methodological variables in the assessment of beta amyloid neurotoxicity

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