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Development and a Practical Synthesis of the JAK2 Inhibitor LY2784544

Organic process research & development, 2012-01, Vol.16 (1), p.70-81

2012

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Multisystem Inflammatory Syndrome in Children—United States, February 2020–July 2021

Clinical infectious diseases, 2022-08, Vol.75 (1), p.e1165-e1175

2022

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Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications

The Journal of biological chemistry, 2013-02, Vol.288 (5), p.3500-3511

2013

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Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

Blood cancer journal (New York), 2013-04, Vol.3 (4), p.e109-e109

2013

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Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration

Molecular cancer therapeutics, 2017-12, Vol.16 (12), p.2677-2688

2017

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Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

BMC genomics, 2008-06, Vol.9 (1), p.264-264, Article 264

2008

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Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1887-1891

2018

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The development of potent and selective bisarylmaleimide GSK3 inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.899-903

2005

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Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells

The Journal of biological chemistry, 2013-02, Vol.288 (5), p.3500-3511

2013

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Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1377-1380

2015

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Asymmetric upwarp of the asthenosphere beneath the Baikal rift zone, Siberia

Journal of Geophysical Research - Solid Earth, 1994-08, Vol.99 (B8), p.15319-15330

1994

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Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model

The Journal of pharmacology and experimental therapeutics, 1996-11, Vol.279 (2), p.732

1996

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Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Cancer management and research, 2011-05, Vol.3 (default), p.157-175

2011

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Improved Performance Rhenium Containing Single Crystal Alloy Turbine Blades Utilizing PPM Levels of the Highly Reactive Elements Lanthanum and Yttrium

Journal of engineering for gas turbines and power, 1999-01, Vol.121 (1), p.138-143

1999

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In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1996-05, Vol.277 (2), p.840

1996

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Development and Turbine Engine Performance of Three Advanced Rhenium Containing Superalloys for Single Crystal and Directionally Solidified Blades and Vanes

Journal of engineering for gas turbines and power, 1998-07, Vol.120 (3), p.595-608

1998

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Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Cancer management and research, 2011, Vol.3, p.157-175

2011

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Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/Tachykinin NK1 receptor antagonist activity

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (22), p.2819-2824

1997

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Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists

Bioorganic & medicinal chemistry letters, 1997-10, Vol.7 (19), p.2531-2536

1997

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Abstract 3042: LY2801653: An orally bioavailable MET kinase inhibitor with inhibitory activity against the oncoproteins ROS1 and MKNK1/2

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3042-3042

2013

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Abstract 2820: LY2784544, a small molecule JAK2 inhibitor, induces apoptosis in inflammatory breast cancer spheres through targeting IL-6-JAK-STAT3 pathway

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2820-2820

2011

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Development and a Practical Synthesis of the JAK2 Inhibitor LY2784544

Multisystem Inflammatory Syndrome in Children—United States, February 2020–July 2021

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications

Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration

Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT

The development of potent and selective bisarylmaleimide GSK3 inhibitors

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Asymmetric upwarp of the asthenosphere beneath the Baikal rift zone, Siberia

Reported cases of multisystem inflammatory syndrome in children aged 12–20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation

Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model

Improved Performance Rhenium Containing Single Crystal Alloy Turbine Blades Utilizing PPM Levels of the Highly Reactive Elements Lanthanum and Yttrium

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist

Development and Turbine Engine Performance of Three Advanced Rhenium Containing Superalloys for Single Crystal and Directionally Solidified Blades and Vanes

Erratum to: Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/Tachykinin NK1 receptor antagonist activity

Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists

Abstract 3042: LY2801653: An orally bioavailable MET kinase inhibitor with inhibitory activity against the oncoproteins ROS1 and MKNK1/2

Abstract 2820: LY2784544, a small molecule JAK2 inhibitor, induces apoptosis in inflammatory breast cancer spheres through targeting IL-6-JAK-STAT3 pathway

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