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Informing and Validating Translational Mechanism‐Based Models for Antibiotics by Experimental and Computational Approaches

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1426-1428

Bulitta, Jürgen B.

2021

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Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

PLoS computational biology, 2016-03, Vol.12 (3), p.e1004782-e1004782

2016

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Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens

Antimicrobial agents and chemotherapy, 2024-04, Vol.68 (4), p.e0140023

2024

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Development of a Physiologically Relevant Population Pharmacokinetic in Vitro–in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

Molecular pharmaceutics, 2017-01, Vol.14 (1), p.53-65

2017

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Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae

Journal of antimicrobial chemotherapy, 2022-02, Vol.77 (2), p.356-363

2022

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Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

Pharmacotherapy, 2010-12, Vol.30 (12), p.1279-1291

2010

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Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics

Pharmaceutical research, 2023-05, Vol.40 (5), p.1177-1191

2023

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Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model

Journal of antimicrobial chemotherapy, 2020-09, Vol.75 (9), p.2622-2632

2020

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Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology

Antimicrobial agents and chemotherapy, 2023-06, Vol.67 (6), p.e0160322-e0160322

2023

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Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

Journal of materials science. Materials in medicine, 2015-02, Vol.26 (2), p.117-7, Article 117

2015

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Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

Antimicrobial agents and chemotherapy, 2017-12, Vol.61 (12)

2017

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High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin

Aquaculture, 2024-01, Vol.579, p.740222, Article 740222

2024

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Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Antimicrobial agents and chemotherapy, 2024-02, Vol.68 (2), p.e0139323

2024

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Novel extended in vitro-in vivo correlation model for the development of extended-release formulations for baclofen: From formulation composition to in vivo pharmacokinetics

International journal of pharmaceutics, 2019-02, Vol.556, p.276-286

2019

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Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models

Antimicrobial agents and chemotherapy, 2024-03, Vol.68 (3), p.e0139423

2024

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Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2334-2343

2014

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Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

Expert review of anti-infective therapy, 2017-06, Vol.15 (6), p.519-526

2017

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Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.3913-3920

2016

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Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity

Antimicrobial agents and chemotherapy, 2022-09, Vol.66 (9), p.e0052722

2022

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Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947-2019

Clinical infectious diseases, 2022-10, Vol.75 (Suppl 3), p.S379-S391

2022

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Distinguishing inducible and non-inducible resistance to colistin in Pseudomonas aeruginosa by Quantitative and Systems Pharmacology modeling at low and standard inocula

Journal of pharmaceutical sciences, 2024-01, Vol.113 (1), p.202-213

2024

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Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

Antimicrobial agents and chemotherapy, 2023-05, Vol.67 (5), p.e0019723

2023

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Synergistic Activity of Colistin and Rifampin Combination against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Antimicrobial Agents and Chemotherapy, 2013-08, Vol.57 (8), p.3738-3745

2013

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Informing and Validating Translational Mechanism‐Based Models for Antibiotics by Experimental and Computational Approaches

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens

Development of a Physiologically Relevant Population Pharmacokinetic in Vitro–in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae

Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics

Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model

Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology

Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin

Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Novel extended in vitro-in vivo correlation model for the development of extended-release formulations for baclofen: From formulation composition to in vivo pharmacokinetics

Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models

Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity

Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947-2019

Distinguishing inducible and non-inducible resistance to colistin in Pseudomonas aeruginosa by Quantitative and Systems Pharmacology modeling at low and standard inocula

Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

Synergistic Activity of Colistin and Rifampin Combination against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacokinetic/Pharmacodynamic Model

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