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The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex

Biochemistry (Easton), 2014-04, Vol.53 (12), p.1908-1915

Bubeck, Doryen

2014

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The mystery behind membrane insertion: a review of the complement membrane attack complex

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2017-08, Vol.372 (1726), p.20160221

2017

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Structural basis of complement membrane attack complex formation

Nature communications, 2016-02, Vol.7 (1), p.10587-10587, Article 10587

2016

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Single-molecule kinetics of pore assembly by the membrane attack complex

Nature communications, 2019-05, Vol.10 (1), p.2066-2066, Article 2066

2019

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Structural basis of soluble membrane attack complex packaging for clearance

Nature communications, 2021-10, Vol.12 (1), p.6086-6086, Article 6086

2021

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AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

PLoS biology, 2023-02, Vol.21 (2), p.e3001962

2023

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CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

Nature communications, 2018-12, Vol.9 (1), p.5316-11, Article 5316

2018

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Structural basis for tuning activity and membrane specificity of bacterial cytolysins

Nature communications, 2020-11, Vol.11 (1), p.5818-10, Article 5818

2020

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Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (42), p.20984-20990

2019

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Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Frontiers in immunology, 2020-11, Vol.11, p.585108-585108

2020

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Structural basis for membrane attack complex inhibition by CD59

Nature communications, 2023-02, Vol.14 (1), p.890-890, Article 890

2023

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Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Nature communications, 2024-03, Vol.15 (1), p.2071-11, Article 2071

2024

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4 Controlling the membrane attack complex

Immunobiology (1979), 2023-09, Vol.228 (5), p.152463, Article 152463

Bubeck, Doryen

2023

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Dynamics and Molecular Interactions of GPI-Anchored CD59

Toxins, 2023-06, Vol.15 (7), p.430

2023

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Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

Cell reports (Cambridge), 2012-03, Vol.1 (3), p.200-207

2012

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PCNA directs type 2 RNase H activity on DNA replication and repair substrates

Nucleic acids research, 2011-05, Vol.39 (9), p.3652-3666

2011

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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

Developmental cell, 2011-11, Vol.21 (5), p.848-861

2011

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The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

The Journal of biological chemistry, 2011-03, Vol.286 (12), p.10530-10539

2011

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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

Scientific reports, 2016-04, Vol.6 (1), p.24656-24656, Article 24656

2016

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Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

Scientific reports, 2016-12, Vol.6 (1), p.38446-38446, Article 38446

2016

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Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity

Wellcome open research, 2023, Vol.8, p.76-76

2023

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Structure of the transmembrane protein 2 (TMEM2) ectodomain and its lack of hyaluronidase activity

Wellcome open research, 2023-02, Vol.8, p.76

2023

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Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

Cell reports (Cambridge), 2013-05, Vol.3 (5), p.1369-1377

2013

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The Structure of the Poliovirus 135S Cell Entry Intermediate at 10-Angstrom Resolution Reveals the Location of an Externalized Polypeptide That Binds to Membranes

Journal of Virology, 2005-06, Vol.79 (12), p.7745-7755

2005

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Unraveling Structural Polymorphism of Amyloid Fibers

Structure (London), 2015-01, Vol.23 (1), p.10-11

Bubeck, Doryen

2015

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The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex

The mystery behind membrane insertion: a review of the complement membrane attack complex

Structural basis of complement membrane attack complex formation

Single-molecule kinetics of pore assembly by the membrane attack complex

Structural basis of soluble membrane attack complex packaging for clearance

AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

Structural basis for tuning activity and membrane specificity of bacterial cytolysins

Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Structural basis for membrane attack complex inhibition by CD59

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

4 Controlling the membrane attack complex

Dynamics and Molecular Interactions of GPI-Anchored CD59

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity

Structure of the transmembrane protein 2 (TMEM2) ectodomain and its lack of hyaluronidase activity

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

The Structure of the Poliovirus 135S Cell Entry Intermediate at 10-Angstrom Resolution Reveals the Location of an Externalized Polypeptide That Binds to Membranes

Unraveling Structural Polymorphism of Amyloid Fibers

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