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Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes

Cell, 2007-12, Vol.131 (6), p.1072-1083

2007

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Are academic drug discovery efforts receiving more recognition with declining industry efficiency?

Expert opinion on drug discovery, 2019-07, Vol.14 (7), p.605-607

2019

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Crowd sourcing in drug discovery

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.241-242

2011

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Oxadiazolone bioisosteres of pregabalin and gabapentin

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.247-250

2009

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New anti-tuberculosis agents amongst known drugs

Tuberculosis (Edinburgh, Scotland), 2009-09, Vol.89 (5), p.364-370

2009

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Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

Tuberculosis (Edinburgh, Scotland), 2011-07, Vol.91 (4), p.277-286

2011

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3-Substituted GABA analogs with central nervous system activity: A review

Medicinal research reviews, 1999-03, Vol.19 (2), p.149-177

1999

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Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5294-5298

2008

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Synthesis and in vivo evaluation of bicyclic gababutins

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.461-464

2010

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Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

Tetrahedron letters, 2011-11, Vol.52 (45), p.5913-5917

2011

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Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam

Tetrahedron, 2003-08, Vol.59 (33), p.6221-6231

2003

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Synthesis and in vivo evaluation of 3-substituted gababutins

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.362-365

2010

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Synthesis and in vivo evaluation of 3,4-disubstituted gababutins

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.248-251

2010

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Part 1: N-Alkylated glycines as potent α₂δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3764-3766

2011

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The synthesis of functionalised β- and γ-lactams by cyclisation of enamides using copper(I) or ruthenium(II)

Tetrahedron letters, 2001-04, Vol.42 (15), p.2901-2905

2001

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Carboxylate bioisosteres of gabapentin

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2333-2336

2006

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Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1838-1845

1998

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Chiral synthesis of 5-hydroxy-(L)-pipecolic acids from (L)-glutamic acid

Tetrahedron letters, 1988, Vol.29 (18), p.2231-2234

1988

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Efficient radical cyclisation of secondary amides: An enantioselective synthesis of phenyl allokainoid

Tetrahedron letters, 1999-04, Vol.40 (17), p.3487-3490

1999

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Crowd sourcing in drug discovery: crowd sourcing is emerging as an open-innovation approach to promote collaboration and harness the complementary expertise of academic and industrial partners in the early stages of drug discovery. Here, we highlight examples of such initiatives and discuss key success factors

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.241

2011

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Chemo-enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase

Tetrahedron, 1997-05, Vol.53 (20), p.7011-7020

1997

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Part 1: N-Alkylated glycines as potent alpha sub(2[delta] ligands)

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3764-3766

2011

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Preparation of triazolobenzodiazepine derivatives as Vasopressin Via antagonists

Tetrahedron letters, 2011, Vol.52 (45)

2011

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Part 1: N-Alkylated glycines as potent α 2δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3764-3766

2011

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Carboxylate bioisosteres of gabapentin Dedicated to David W. Robertson in memory of his outstanding contributions as a mentor and drug hunter

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (9), p.2333-2336

2006

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Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes

Are academic drug discovery efforts receiving more recognition with declining industry efficiency?

Crowd sourcing in drug discovery

Oxadiazolone bioisosteres of pregabalin and gabapentin

New anti-tuberculosis agents amongst known drugs

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

3-Substituted GABA analogs with central nervous system activity: A review

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

Synthesis and in vivo evaluation of bicyclic gababutins

Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

Metal-catalysed radical cyclisations leading to N-heterocycles: new approaches to gabapentin and pulchellalactam

Synthesis and in vivo evaluation of 3-substituted gababutins

Synthesis and in vivo evaluation of 3,4-disubstituted gababutins

Part 1: N-Alkylated glycines as potent α₂δ ligands

The synthesis of functionalised β- and γ-lactams by cyclisation of enamides using copper(I) or ruthenium(II)

Carboxylate bioisosteres of gabapentin

Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents

Chiral synthesis of 5-hydroxy-(L)-pipecolic acids from (L)-glutamic acid

Efficient radical cyclisation of secondary amides: An enantioselective synthesis of phenyl allokainoid

Chemo-enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase

Part 1: N-Alkylated glycines as potent alpha sub(2[delta] ligands)

Preparation of triazolobenzodiazepine derivatives as Vasopressin Via antagonists

Part 1: N-Alkylated glycines as potent α 2δ ligands

Carboxylate bioisosteres of gabapentin Dedicated to David W. Robertson in memory of his outstanding contributions as a mentor and drug hunter

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