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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324-333

2016

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Examining the associations between self-care practices and psychological distress among nursing students during the COVID-19 pandemic

Nurse education today, 2021-05, Vol.100, p.104864-104864, Article 104864

2021

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Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.126-141

2013

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In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.95-112

2013

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A Perspective on Efflux Transport Proteins in the Liver

Clinical pharmacology and therapeutics, 2012-11, Vol.92 (5), p.599-612

2012

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Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3194-3201

2013

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In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Clinical pharmacology and therapeutics, 2007-03, Vol.81 (3), p.406-413

2007

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Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat

Drug metabolism and disposition, 1999-07, Vol.27 (7), p.827

1999

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P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

Biochemical pharmacology, 1999-09, Vol.58 (6), p.951-957

1999

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Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Clinical pharmacology and therapeutics, 2015-09, Vol.98 (3), p.266-287

2015

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Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

Pharmaceutical research, 1998-04, Vol.15 (4), p.599-605

1998

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

Pharmaceutical research, 1999-08, Vol.16 (8), p.1206-1212

1999

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Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration

Pharmaceutical research, 1998-10, Vol.15 (10), p.1533-1539

1998

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Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Clinical pharmacology and therapeutics, 2014-11, Vol.96 (5), p.589-598

2014

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Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes

Drug metabolism and disposition, 2016-06, Vol.44 (6), p.867-870

2016

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Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver

Cancer research (Chicago, Ill.), 1998-08, Vol.58 (16), p.3641-3648

1998

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Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.419-427

2015

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Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats

Drug metabolism and disposition, 1999-06, Vol.27 (6), p.637

1999

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Automatic training of a min-max neural network for function approximation by using a second feed forward network

Soft computing (Berlin, Germany), 2005-05, Vol.9 (5), p.393-397

Brouwer, R. K.

2005

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Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

American journal of physiology: Gastrointestinal and liver physiology, 1999-07, Vol.277 (1), p.G12-G21

1999

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Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.754

2001

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Automatic growing of a Hopfield style network during training for classification

Neural networks, 1997-04, Vol.10 (3), p.529-537

BROUWER, R. K

1997

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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

CPT: pharmacometrics and systems pharmacology, 2014-07, Vol.3 (7), p.1-8

2014

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Set oriented mappings on neural networks

Soft computing (Berlin, Germany), 2003-10, Vol.8 (1), p.28-37

2003

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Examining the associations between self-care practices and psychological distress among nursing students during the COVID-19 pandemic

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

A Perspective on Efflux Transport Proteins in the Liver

Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat

P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity

Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes

Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats

Automatic training of a min-max neural network for function approximation by using a second feed forward network

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Automatic growing of a Hopfield style network during training for classification

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

Set oriented mappings on neural networks

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