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GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

Diabetologia, 2014-06, Vol.57 (6), p.1182-1191

2014

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Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5361-5379

2012

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Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

Diabetes (New York, N.Y.), 2004-03, Vol.53 (3), p.535-541

2004

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The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119

British journal of pharmacology, 2012-04, Vol.165 (8), p.2758-2770

2012

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Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.8984-8998

2014

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Conformational restriction in a series of GPR119 agonists: Differences in pharmacology between mouse and human

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3175-3179

2013

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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7310-7316

2011

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Differences in regulatory properties between human and rat glucokinase regulatory protein

Biochemical journal, 2004-03, Vol.378 (Pt 2), p.693-697

2004

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Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

FEBS letters, 1994-10, Vol.353 (1), p.33-36

1994

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

MedChemComm, 2013, Vol.4 (1), p.95-100

2013

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonistsThis article is part of a MedChemComm 'New Talents' issue highlighting the work of outstanding rising scientists in medicinal chemistry research.Electronic supplementary information (ESI) available: Synthetic details for the synthesis of 11 and crystallographic data for 13. See DOI: 10.1039/c2md20130e

2012-12

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Acute Administration of Fructose, with Glucose, Causes a Significant Decrease in Early Plasma Glucose Levels in Rodents.(Brief Article)

Diabetes (New York, N.Y.), 2000-05, Vol.49 (5), p.A278

2000

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4 Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by β2-adrenergic agonists

Biochemical Society transactions, 1998-11, Vol.26 (4), p.S311-S311

1998

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Clenbuterol is not an agonist of Na+ dependent creatine transport

Biochemical Society transactions, 1996-05, Vol.24 (2), p.215S-215S

1996

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Anabolic effects of a range of β2-adrenoceptor agonists in a clonal G8.P8 cell line

Biochemical Society transactions, 1996, Vol.24 (2), p.214-214S

1996

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GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119

Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists

Conformational restriction in a series of GPR119 agonists: Differences in pharmacology between mouse and human

Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Differences in regulatory properties between human and rat glucokinase regulatory protein

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

Acute Administration of Fructose, with Glucose, Causes a Significant Decrease in Early Plasma Glucose Levels in Rodents.(Brief Article)

4 Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by β2-adrenergic agonists

Clenbuterol is not an agonist of Na+ dependent creatine transport

Anabolic effects of a range of β2-adrenoceptor agonists in a clonal G8.P8 cell line

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