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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Cerebral cortex (New York, N.Y. 1991), 2016-01, Vol.26 (1), p.414-426

2016

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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

The Journal of clinical investigation, 2017-02, Vol.127 (2), p.487-499

2017

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Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors

The European journal of neuroscience, 2017-06, Vol.45 (12), p.1570-1585

2017

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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2

Experimental physiology, 2024-01, Vol.109 (1), p.81-99

2024

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TRPV3 in Drug Development

Pharmaceuticals (Basel, Switzerland), 2016-09, Vol.9 (3), p.55

2016

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Mechanisms of capacitative calcium entry

Journal of cell science, 2001-06, Vol.114 (Pt 12), p.2223-2229

2001

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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist

Neuropharmacology, 2017-03, Vol.115, p.100-114

2017

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Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases

Neuropharmacology, 2018-07, Vol.136 (Pt C), p.449-458

2018

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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease

Cell, 2021-11, Vol.184 (24), p.5886

2021

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Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators

The Journal of pharmacology and experimental therapeutics, 2006-09, Vol.318 (3), p.1108-1117

2006

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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Nature chemical biology, 2020-03, Vol.16 (3), p.240-249

2020

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TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology

Clinical pharmacology and therapeutics, 2023-11, Vol.114 (5), p.1093-1103

2023

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A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin

The Journal of physiology, 1999-05, Vol.517 (1), p.121-134

1999

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Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

Molecular pharmacology, 2018-06, Vol.93 (6), p.645-656

2018

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Bitopic Binding Mode of an M 1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

Molecular pharmacology, 2018-06, Vol.93 (6), p.645-656

2018

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An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.8862-8875

2016

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Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons

Psychopharmacology, 2014-03, Vol.231 (6), p.1105-1124

2014

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Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors

British journal of pharmacology, 2019-01, Vol.176 (1), p.110-126

2019

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In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography

The Journal of pharmacology and experimental therapeutics, 2018-06, Vol.365 (3), p.602-613

2018

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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist

Neuropharmacology, 2017-03, Vol.115, p.100-114

2017

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Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells

Biochemical journal, 2005-08, Vol.389 (Pt 3), p.821-829

2005

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In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Neuropharmacology, 2013-01, Vol.64, p.224-239

2013

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Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

Molecular pharmacology, 2008-06, Vol.73 (6), p.1838-1843

2008

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Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

Brain research, 2009-03, Vol.1260, p.65-75

2009

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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors

The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2

TRPV3 in Drug Development

Mechanisms of capacitative calcium entry

In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist

Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology

A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin

Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

Bitopic Binding Mode of an M 1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons

Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors

In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography

In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist

Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

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