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Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease

The Journal of pharmacology and experimental therapeutics, 2011-01, Vol.336 (1), p.38

2011

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Localization of histamine H4 receptors in the central nervous system of human and rat

Brain research, 2009-01, Vol.1250, p.41-48

2009

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A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

Journal of anesthesia, 2017-10, Vol.31 (5), p.764-778

2017

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Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

Pain (Amsterdam), 2005-09, Vol.117 (1), p.88-96

2005

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Activation of Dopamine D4 Receptors by ABT-724 Induces Penile Erection in Rats

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (17), p.6758-6763

2004

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Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine

The Journal of pharmacology and experimental therapeutics, 2004-01, Vol.308 (1), p.330-338

2004

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In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

Neuropharmacology, 2011-02, Vol.60 (2-3), p.460-466

2011

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Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

Journal of medicinal chemistry, 2009-01, Vol.52 (1), p.170-180

2009

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Antagonism of supraspinal histamine H3 receptors modulates spinal neuronal activity in neuropathic rats

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.13

2012

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Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats

European journal of pharmacology, 2008-02, Vol.580 (3), p.314-321

2008

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A-412997 is a selective dopamine D4 receptor agonist in rats

Pharmacology, biochemistry and behavior, 2005-09, Vol.82 (1), p.140-147

2005

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Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4640-4649

2009

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Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

Biochemical pharmacology, 2007-04, Vol.73 (8), p.1243-1255

2007

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Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator

Journal of Pharmacological Sciences, 2006, Vol.102(2), pp.231-238

2006

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Emerging pharmacologic approaches for the treatment of lower urinary tract disorders

The Journal of pharmacology and experimental therapeutics, 2004-03, Vol.308 (3), p.797-804

2004

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Association of Catsper1 or -2 with Cav3.3 Leads to Suppression of T-type Calcium Channel Activity

The Journal of biological chemistry, 2006-08, Vol.281 (31), p.22332-22341

2006

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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

Neuropharmacology, 2007-03, Vol.52 (4), p.1095-1105

2007

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Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

Clinical and experimental pharmacology & physiology, 2004-12, Vol.31 (12), p.837-841

2004

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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Pharmacology, biochemistry and behavior, 2010-03, Vol.95 (1), p.41-50

2010

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YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats

European journal of pharmacology, 2003, Vol.458 (1), p.183-189

2003

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Pharmacological and molecular analysis of ATP-sensitive K + channels in the pig and human detrusor

European journal of pharmacology, 2000-07, Vol.400 (2), p.287-295

2000

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Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.233

2012

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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6547-6557

2008

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Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists

Bioorganic & medicinal chemistry, 2004-07, Vol.12 (13), p.3471-3483

2004

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The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons

Neurochemistry international, 2008-09, Vol.53 (3), p.79-88

2008

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Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease

Localization of histamine H4 receptors in the central nervous system of human and rat

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

Activation of Dopamine D4 Receptors by ABT-724 Induces Penile Erection in Rats

Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

Antagonism of supraspinal histamine H3 receptors modulates spinal neuronal activity in neuropathic rats

Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats

A-412997 is a selective dopamine D4 receptor agonist in rats

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator

Emerging pharmacologic approaches for the treatment of lower urinary tract disorders

Association of Catsper1 or -2 with Cav3.3 Leads to Suppression of T-type Calcium Channel Activity

Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats

Pharmacological and molecular analysis of ATP-sensitive K + channels in the pig and human detrusor

Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons

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