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Sirtuins - novel therapeutic targets to treat age-associated diseases

Nature reviews. Drug discovery, 2008-10, Vol.7 (10), p.841-853

2008

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Nature, 2007-11, Vol.450 (7170), p.712-716

2007

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Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

Genes & development, 2010-07, Vol.24 (13), p.1403-1417

2010

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Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Cell, 2005-11, Vol.123 (3), p.493-505

2005

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Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

Neuron (Cambridge, Mass.), 2006-07, Vol.51 (2), p.239-249

2006

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Recruitment of brown adipose tissue as a therapy for obesity-associated diseases

Frontiers in endocrinology (Lausanne), 2012, Vol.3, p.14-14

2012

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Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Nature (London), 2001-02, Vol.409 (6821), p.729-733

2001

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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Molecular and Cellular Biology, 2000-08, Vol.20 (15), p.5479-5489

2000

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The obesity epidemic : Current and future pharmacological treatments

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.565-592

2007

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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

BMC systems biology, 2009-03, Vol.3 (1), p.31-31, Article 31

2009

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Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

The Journal of biological chemistry, 2000-05, Vol.275 (21), p.16258-16266

2000

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Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

The Journal of biological chemistry, 1998-01, Vol.273 (1), p.5-8

1998

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Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold

FEBS letters, 1997-07, Vol.412 (1), p.111-114

1997

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Overexpression of the LAR (Leukocyte Antigen-Related) Protein-Tyrosine Phosphatase in Muscle Causes Insulin Resistance

Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (9), p.5187-5192

2001

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Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat

The FASEB journal, 1998-03, Vol.12 (3), p.335-339

1998

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Targeting PGC-1α to control energy homeostasis

Expert opinion on therapeutic targets, 2007-10, Vol.11 (10), p.1329-1338

2007

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Resveratrol improves health and survival of mice on a high-calorie diet

Nature, 2006-11, Vol.444 (7117), p.337-342

2006

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Cloning and functional characterization of an uncoupling protein homolog in hummingbirds

Physiological genomics, 2001-04, Vol.5 (3), p.137-145

2001

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Nature (London), 2002-08, Vol.418 (6899), p.797-801

2002

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism

Diabetes (New York, N.Y.), 2000-02, Vol.49 (2), p.143-156

2000

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Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

Cell, 2001-06, Vol.105 (6), p.745-755

2001

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

FEBS letters, 1997-05, Vol.408 (1), p.39-42

1997

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Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases

Nature reviews. Drug discovery, 2009-06, Vol.8 (6), p.516-516

2009

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The uncoupling proteins, a review

European journal of endocrinology, 1998-07, Vol.139 (1), p.1-9

1998

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Direct effects of leptin on brown and white adipose tissue

The Journal of clinical investigation, 1997-12, Vol.100 (11), p.2858-2864

1997

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Sirtuins - novel therapeutic targets to treat age-associated diseases

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

Recruitment of brown adipose tissue as a therapy for obesity-associated diseases

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

The obesity epidemic : Current and future pharmacological treatments

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold

Overexpression of the LAR (Leukocyte Antigen-Related) Protein-Tyrosine Phosphatase in Muscle Causes Insulin Resistance

Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat

Targeting PGC-1α to control energy homeostasis

Resveratrol improves health and survival of mice on a high-calorie diet

Cloning and functional characterization of an uncoupling protein homolog in hummingbirds

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases

The uncoupling proteins, a review

Direct effects of leptin on brown and white adipose tissue

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