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Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Journal of medicinal chemistry, 2001-11, Vol.44 (23), p.3965-3977

2001

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Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles

Journal of medicinal chemistry, 2001-03, Vol.44 (5), p.822-833

2001

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Synergistic activity of the Src Abl inhibitor bosutinib in combination with imatinib

Leukemia, 2010-06, Vol.24 (6), p.1223-1227

2010

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Control of mammary tumor differentiation by SKI-606 (bosutinib)

Oncogene, 2011-01, Vol.30 (3), p.301-312

2011

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SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

Cancer research (Chicago, Ill.), 2003-01, Vol.63 (2), p.375-381

2003

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Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis

Molecular and Cellular Biology, 1993-08, Vol.13 (8), p.5112-5121

BOSCHELLI, F

1993

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7-alkoxy-4-phenylamino-3-quinolinecarbonitriles as dual inhibitors of Src and Abl kinases

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1599-1601

2004

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Synthesis and Src Kinase Inhibitory Activity of 2-Phenyl- and 2-Thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3891-3902

2005

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Identification of 7-Phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a New Class of Src Kinase Inhibitors

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6666-6668

2004

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Identification of a Conserved Sequence Motif That Promotes Cdc37 and Cyclin D1 Binding to Cdk4

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12560-12564

2004

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4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.5909-5920

2005

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Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2477-2480

2000

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Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2- b]pyridine-6-carbonitriles

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4681-4684

2005

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Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5- b]quinolines

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.2977-2980

2003

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Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2155-2158

2004

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Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.2011-2014

2002

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CDC37 is required for p60v-src activity in yeast

Molecular biology of the cell, 1996-09, Vol.7 (9), p.1405-1417

1996

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Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3797-3800

2003

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Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2989-2992

2002

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Small molecule inhibitors of Src family kinases

Drugs of the Future, 2000, Vol.25 (7), p.717

2000

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Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis

Molecular and cellular biology, 1994-09, Vol.14 (9), p.6409-6409

Boschelli, F

1994

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The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain

Journal of cell science, 1993-06, Vol.105 ( Pt 2) (2), p.519-528

1993

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THE DUAL SRC/ABL KINASE INHIBITOR SKI-606 EFFECTIVELY INHIBITS BCR-ABL KINASE ACTIVITY IN CHRONIC MYELOGENOUS LEUKEMIA PRIMITIVE PROGENITOR CELLS: 14

Journal of investigative medicine, 2007-01, Vol.55 (1), p.S78

2007

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THE DUAL SRC/ABL KINASE INHIBITOR SKI-606 EFFECTIVELY INHIBITS BCR-ABL KINASE ACTIVITY IN CHRONIC MYELOGENOUS LEUKEMIA PRIMITIVE PROGENITOR CELLS: 400

Journal of investigative medicine, 2007-01, Vol.55 (1), p.S141

2007

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8-Anilinoimidazo[4,5- g]quinoline-7-carbonitriles as Src Kinase Inhibitors

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (19), p.2761-2765

2002

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Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles

Synergistic activity of the Src Abl inhibitor bosutinib in combination with imatinib

Control of mammary tumor differentiation by SKI-606 (bosutinib)

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis

7-alkoxy-4-phenylamino-3-quinolinecarbonitriles as dual inhibitors of Src and Abl kinases

Synthesis and Src Kinase Inhibitory Activity of 2-Phenyl- and 2-Thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles

Identification of 7-Phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a New Class of Src Kinase Inhibitors

Identification of a Conserved Sequence Motif That Promotes Cdc37 and Cyclin D1 Binding to Cdk4

4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2- b]pyridine-6-carbonitriles

Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5- b]quinolines

Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles

Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

CDC37 is required for p60v-src activity in yeast

Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity

Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

Small molecule inhibitors of Src family kinases

Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis

The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain

THE DUAL SRC/ABL KINASE INHIBITOR SKI-606 EFFECTIVELY INHIBITS BCR-ABL KINASE ACTIVITY IN CHRONIC MYELOGENOUS LEUKEMIA PRIMITIVE PROGENITOR CELLS: 14

THE DUAL SRC/ABL KINASE INHIBITOR SKI-606 EFFECTIVELY INHIBITS BCR-ABL KINASE ACTIVITY IN CHRONIC MYELOGENOUS LEUKEMIA PRIMITIVE PROGENITOR CELLS: 400

8-Anilinoimidazo[4,5- g]quinoline-7-carbonitriles as Src Kinase Inhibitors

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