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Roles and mechanisms of alternative splicing in cancer - implications for care

Nature reviews. Clinical oncology, 2020-08, Vol.17 (8), p.457-474

2020

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The spliceosome as a target of novel antitumour drugs

Nature reviews. Drug discovery, 2012-11, Vol.11 (11), p.847-859

2012

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In silico RNA isoform screening to identify potential cancer driver exons with therapeutic applications

Nature communications, 2024-08, Vol.15 (1), p.7039-19

2024

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Structural basis for specific RNA recognition by the alternative splicing factor RBM5

Nature communications, 2023-07, Vol.14 (1), p.4233-4233, Article 4233

2023

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Multi―domain conformational selection underlies pre―mRNA splicing regulation by U2AF

Nature (London), 2011-07, Vol.475 (7356), p.408-411

2011

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Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

Molecular cell, 2005-08, Vol.19 (4), p.475-484

2005

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Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation

eLife, 2016-11, Vol.5

2016

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U2AF-homology motif interactions are required for alternative splicing regulation by SPF45

Nature structural & molecular biology, 2007-07, Vol.14 (7), p.620-629

2007

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Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs

Molecular biology of the cell, 2007-12, Vol.18 (12), p.5048-5059

2007

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A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation

Science advances, 2022-04, Vol.8 (15), p.eabn4935-eabn4935

2022

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Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation

Scientific reports, 2018-11, Vol.8 (1), p.16719-10, Article 16719

2018

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Heterogeneous Nuclear Ribonucleoprotein A1 Is a Novel Internal Ribosome Entry Site trans-Acting Factor That Modulates Alternative Initiation of Translation of the Fibroblast Growth Factor 2 mRNA

The Journal of biological chemistry, 2005-02, Vol.280 (6), p.4144-4153

2005

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A Single Internal Ribosome Entry Site Containing a G Quartet RNA Structure Drives Fibroblast Growth Factor 2 Gene Expression at Four Alternative Translation Initiation Codons

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.39330-39336

2003

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Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons

Biology of the Cell, 2003-05, Vol.95 (3), p.169-178

2003

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Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

RNA (Cambridge), 2009-04, Vol.15 (4), p.515-523

2009

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Alternative splicing decouples local from global PRC2 activity

Molecular cell, 2024-03, Vol.84 (6), p.1049-1061.e8

2024

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Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma

Cell reports (Cambridge), 2024-04, Vol.43 (4), p.114048-114048, Article 114048

2024

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RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Molecular cell, 2008-10, Vol.32 (1), p.81-95

2008

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Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (29), p.e2117090119

2022

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RNAtomy of the Spliceosome's heart

The EMBO journal, 2013-10, Vol.32 (21), p.2785-2787

2013

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Spliceosome meets telomerase: the spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends

Nature (London), 2008-12, Vol.456 (7224), p.879

2008

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Spliceosome meets telomerase

Nature (London), 2008-12, Vol.456 (7224), p.879-880

2008

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Pancreatic microexons regulate islet function and glucose homeostasis

Nature metabolism, 2023-02, Vol.5 (2), p.219

2023

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Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation

Molecular biology of the cell, 2007-04, Vol.18 (4), p.1302-1311

2007

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Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis

PNAS nexus, 2022-09, Vol.1 (4), p.pgac222-pgac222

2022

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Roles and mechanisms of alternative splicing in cancer - implications for care

The spliceosome as a target of novel antitumour drugs

In silico RNA isoform screening to identify potential cancer driver exons with therapeutic applications

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

Multi―domain conformational selection underlies pre―mRNA splicing regulation by U2AF

Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45

Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs

A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation

Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation

Heterogeneous Nuclear Ribonucleoprotein A1 Is a Novel Internal Ribosome Entry Site trans-Acting Factor That Modulates Alternative Initiation of Translation of the Fibroblast Growth Factor 2 mRNA

A Single Internal Ribosome Entry Site Containing a G Quartet RNA Structure Drives Fibroblast Growth Factor 2 Gene Expression at Four Alternative Translation Initiation Codons

Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons

Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

Alternative splicing decouples local from global PRC2 activity

Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma

RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision

RNAtomy of the Spliceosome's heart

Spliceosome meets telomerase: the spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends

Spliceosome meets telomerase

Pancreatic microexons regulate islet function and glucose homeostasis

Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation

Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis

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