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Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects

The AAPS journal, 2009-03, Vol.11 (1), p.45-53

2009

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The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1808-1818

2016

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Advanced drug delivery reviews, 2001-10, Vol.50, p.S41-S67

2001

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Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

The Journal of pharmacology and experimental therapeutics, 1988-08, Vol.246 (2), p.803

1988

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Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

Journal of pharmaceutical sciences, 1998-11, Vol.87 (11), p.1286-1291

1998

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Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

European journal of pharmacology, 1989-07, Vol.166 (2), p.325-329

1989

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Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Journal of controlled release, 1999-11, Vol.62 (1-2), p.129-140

1999

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Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Investigative ophthalmology & visual science, 1998-11, Vol.39 (12), p.2365-2373

1998

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Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

Journal of neurochemistry, 1991-11, Vol.57 (5), p.1818-1821

1991

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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

The Journal of pharmacology and experimental therapeutics, 1997-03, Vol.280 (3), p.1284

1997

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In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

Psychopharmacologia, 1999-02, Vol.141 (4), p.339-350

1999

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Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells

Brain research, 1986-06, Vol.375 (2), p.413-416

1986

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In vitro and in vivo activity of 16,17-dehydro-epipregnanolones : 17,20-bond torsional energy analysis and D-ring conformation

Pharmaceutical research, 1996-10, Vol.13 (10), p.1488-1494

1996

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Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

The AAPS journal, 2008, Vol.10 (1), p.213-226

2008

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Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

The Journal of pharmacology and experimental therapeutics, 1996-02, Vol.276 (2), p.667

1996

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In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Molecular pharmaceutics, 2012-03, Vol.9 (3), p.492-504

2012

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Haloperidol binding to monoclonal antibodies. Predictions of three-dimensional combining site structure via computer modeling

The Journal of biological chemistry, 1988-03, Vol.263 (9), p.4064-4074

1988

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

Biochemical and biophysical research communications, 1998-09, Vol.250 (1), p.103-107

1998

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Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding

Molecular pharmacology, 1986-06, Vol.29 (6), p.589-598

1986

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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The AAPS journal, 2009-06, Vol.11 (2), p.323-334

2009

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Haloperidol binding to monoclonal antibodies. Hypervariable region amino acid sequence determination

The Journal of biological chemistry, 1988-03, Vol.263 (9), p.4059-4063

1988

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In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Pharmaceutical research, 2006-08, Vol.23 (8), p.1712-1720

2006

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Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors

Psychopharmacology, 2001-10, Vol.157 (4), p.401-410

2001

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Interaction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNA(Ser)-tRNA(Met) genes

The Journal of biological chemistry, 1989-11, Vol.264 (32), p.19221-19227

1989

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Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects

The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells

Differential Responses of Expressed Recombinant Human γ‐Aminobutyric AcidA Receptors to Neurosteroids

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor

In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells

In vitro and in vivo activity of 16,17-dehydro-epipregnanolones : 17,20-bond torsional energy analysis and D-ring conformation

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice

In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Haloperidol binding to monoclonal antibodies. Predictions of three-dimensional combining site structure via computer modeling

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

Haloperidol binding to monoclonal antibodies. Hypervariable region amino acid sequence determination

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors

Interaction of yeast transcription factor IIIC with dimeric Schizosaccharomyces pombe tRNA(Ser)-tRNA(Met) genes

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