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Effects of channel modulators on cloned large-conductance calcium-activated potassium channels

Molecular pharmacology, 1996-07, Vol.50 (1), p.206

1996

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Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits

Nature neuroscience, 1998-10, Vol.1 (6), p.462-469

1998

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Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices

Journal of neurophysiology, 1992-08, Vol.68 (2), p.629-638

1992

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Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study

Neuroscience, 1992-06, Vol.48 (4), p.807-812

1992

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Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2887-2896

2004

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The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro

Neuropharmacology, 1993-02, Vol.32 (2), p.149-155

1993

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Effects of apomorphine, TL-99 and 3-PPP on yawning in rats

Neuropharmacology, 1984, Vol.23 (1), p.19-22

1984

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Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective Properties

Journal of medicinal chemistry, 2002-03, Vol.45 (7), p.1487-1499

2002

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The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

Bioorganic & medicinal chemistry letters, 2002-07, Vol.12 (13), p.1779-1783

2002

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The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels

Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (7), p.1023-1026

2002

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Suppressant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons

Pharmacology, biochemistry and behavior, 1985-07, Vol.23 (1), p.93-97

1985

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4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.2819-2822

2003

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The discovery of novel openers of Ca2+-dependent large-conductance potassium channels : Pharmacophore search and physiological evaluation of flavonoids

Bioorganic & medicinal chemistry letters, 1997-04, Vol.7 (7), p.759-762

1997

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The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats

Pharmacology, biochemistry and behavior, 1983-01, Vol.19 (4), p.719-723

1983

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Facilitation of shock-induced fighting in the rat after DSP-4, a selective noradrenergic neurotoxin

Pharmacology, biochemistry and behavior, 1983-04, Vol.18 (4), p.625-628

1983

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Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2801-2804

1993

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3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (20), p.5089-5093

2004

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Phenotypic Alteration of a Human BK ( hSlo ) Channel by hSloβ Subunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation

The Journal of neuroscience, 1996-08, Vol.16 (15), p.4543-4550

1996

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Discovery of a novel class of BK channel openers : Enantiospecific synthesis and BK channel opening activity of 3-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-3-hydroxy-6-(trifluoromethyl)-2H-indol-2-one

Bioorganic & medicinal chemistry letters, 1997-05, Vol.7 (10), p.1255-1260

1997

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4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4479-4482

2004

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The synthesis and structure–activity relationships of 3-amino-4-benzylquinolin-2-ones: discovery of novel KCNQ2 channel openers

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1615-1618

2004

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( S)- N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2 H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1991-1995

2004

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Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1 H-indol-5-yl)-ethyl acrylamides

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4533-4537

2004

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4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.2942-2952

2002

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Effects of channel modulators on cloned large-conductance calcium-activated potassium channels

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits

Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices

Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study

Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers

The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro

Effects of apomorphine, TL-99 and 3-PPP on yawning in rats

Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective Properties

The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels

Suppressant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction

The discovery of novel openers of Ca2+-dependent large-conductance potassium channels : Pharmacophore search and physiological evaluation of flavonoids

The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats

Facilitation of shock-induced fighting in the rat after DSP-4, a selective noradrenergic neurotoxin

Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

Phenotypic Alteration of a Human BK ( hSlo ) Channel by hSloβ Subunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation

Discovery of a novel class of BK channel openers : Enantiospecific synthesis and BK channel opening activity of 3-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-3-hydroxy-6-(trifluoromethyl)-2H-indol-2-one

4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle

The synthesis and structure–activity relationships of 3-amino-4-benzylquinolin-2-ones: discovery of novel KCNQ2 channel openers

( S)- N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2 H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1 H-indol-5-yl)-ethyl acrylamides

4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels

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