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Reaction phenotyping for non-CYP, phase 1 enzymes

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S1-S1

Bohnert, Tonika

2018

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Mechanism of Drug-Drug Interactions Between Warfarin and Statins

Journal of pharmaceutical sciences, 2016-06, Vol.105 (6), p.1976-1986

2016

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Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Fluids and barriers of the CNS, 2018-03, Vol.15 (1), p.10-10, Article 10

2018

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Comparison of enzyme kinetics of warfarin analyzed by LC–MS/MS QTrap and differential mobility spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-01, Vol.1008, p.164-173

2016

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Plasma protein binding: From discovery to development

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.2953-2994

2013

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Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12526-12541

2020

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Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1399-1423

2016

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Fampridine is a substrate and inhibitor of human OCT2, but not MATE1 and MATE2K

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S90-S90

2018

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Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.2985-2990

2015

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129108, Article 129108

2023

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116275-116275, Article 116275

2021

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Mechanism of Drug-Drug Interactions Between Warfarin and Statins: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Journal of pharmaceutical sciences, 2016-06, Vol.105 (6), p.1976-1986

2016

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Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.2991-2997

2015

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Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective

Drug discovery today, 2017-10, Vol.22 (10), p.1447-1459

2017

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Abstract C186: SNS-062 is a potent noncovalent BTK inhibitor with comparable activity against wild type BTK and BTK with an acquired resistance mutation

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C186-C186

2015

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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5‘-(2-Phosphoryl-1,4-dioxobutane) as a Product of 5‘-Oxidation of Deoxyribose in DNA: Elimination as trans-1,4-Dioxo-2-butene and Approaches to Analysis

Chemical research in toxicology, 2004-11, Vol.17 (11), p.1406-1413

2004

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Reaction of 2′-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene

Biochemical and biophysical research communications, 2004-10, Vol.323 (3), p.838-844

2004

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A 2 A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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The Effects of Arginine Vasopressin and Acetazolamide on CNS Clearance of Acetaminophen and Ibuprofen in Rats

Journal of Neurology & Neuromedicine, 2018-09, Vol.3 (5), p.51-56

2018

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The Role of Drug Metabolism in Drug Discovery

Enzyme Inhibition in Drug Discovery and Development, 2009, p.91-176

2009

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2 A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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Reaction phenotyping for non-CYP, phase 1 enzymes

Mechanism of Drug-Drug Interactions Between Warfarin and Statins

Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Comparison of enzyme kinetics of warfarin analyzed by LC–MS/MS QTrap and differential mobility spectrometry

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

Plasma protein binding: From discovery to development

Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Fampridine is a substrate and inhibitor of human OCT2, but not MATE1 and MATE2K

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Mechanism of Drug-Drug Interactions Between Warfarin and Statins: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective

Abstract C186: SNS-062 is a potent noncovalent BTK inhibitor with comparable activity against wild type BTK and BTK with an acquired resistance mutation

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

5‘-(2-Phosphoryl-1,4-dioxobutane) as a Product of 5‘-Oxidation of Deoxyribose in DNA: Elimination as trans-1,4-Dioxo-2-butene and Approaches to Analysis

Reaction of 2′-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A 2 A Receptor Antagonists

The Effects of Arginine Vasopressin and Acetazolamide on CNS Clearance of Acetaminophen and Ibuprofen in Rats

The Role of Drug Metabolism in Drug Discovery

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2 A Receptor Antagonists

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