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Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

Physiological reviews, 2011-04, Vol.91 (2), p.651-690

2011

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Chronic lithium treatment induces novel patterns of pendrin localization and expression

American journal of physiology. Renal physiology, 2018-08, Vol.315 (2), p.F313-F322

2018

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Molecular mechanisms of urea transport in health and disease

Pflügers Archiv, 2012-12, Vol.464 (6), p.561-572

2012

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Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice

American journal of physiology. Renal physiology, 2012-01, Vol.302 (1), p.F78-F84

2012

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Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

PloS one, 2015-10, Vol.10 (10), p.e0139756-e0139756

2015

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Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

American Journal of Physiology. Renal Physiology, 2008-07, Vol.295 (1), p.F295-F299

2008

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Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus

PloS one, 2014-07, Vol.9 (7), p.e101753

2014

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Forskolin stimulates phosphorylation and membrane accumulation of UT-A3

American journal of physiology. Renal physiology, 2007-10, Vol.293 (4), p.F1308-F1313

2007

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Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

Molecular pharmacology, 2004-07, Vol.66 (1), p.144-152

2004

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miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export

American Journal of Physiology: Cell Physiology, 2014-03, Vol.306 (6), p.C551-C558

2014

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Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)

Neurochemistry international, 2004-11, Vol.45 (6), p.859-863

2004

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Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts

American journal of physiology. Renal physiology, 2016-05, Vol.310 (10), p.F1008-F1012

2016

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Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity

American Journal of Physiology - Renal Physiology, 2008-11, Vol.295 (5), p.F1336-F1341

2008

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A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization

Molecular pharmacology, 2006-11, Vol.70 (5), p.1822-1831

2006

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Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.730-737

2007

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Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.62-68

2008

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The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus

Frontiers in physiology, 2012-01, Vol.3, p.176-176

2012

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Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

American journal of physiology. Renal physiology, 2019-03, Vol.316 (3), p.F539-F549

2019

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High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors

Biochemical and biophysical research communications, 2005-09, Vol.334 (3), p.930-938

2005

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Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3

Journal of the American Society of Nephrology, 2016-05, Vol.27 (5), p.1448-1455

2016

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Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration"

American Journal of Physiology: Cell Physiology, 2014-10, Vol.307 (7), p.C595-C596

2014

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[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

Molecular pharmacology, 2003-06, Vol.63 (6), p.1364-1372

2003

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Genes and proteins of urea transporters

Sub-cellular biochemistry, 2014, Vol.73, p.45

2014

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A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct

American Journal of Physiology - Renal Physiology, 2010-04, Vol.298 (4), p.F857-F858

Blount, Mitsi A

2010

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Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure

American journal of physiology. Renal physiology, 2014-03, Vol.306 (6), p.F597-F607

2014

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Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

Chronic lithium treatment induces novel patterns of pendrin localization and expression

Molecular mechanisms of urea transport in health and disease

Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3

Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5)

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity

A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization

Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors

Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3

Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration"

[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

Genes and proteins of urea transporters

A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct

Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure

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