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Pipeline for contraceptive development

Fertility and sterility, 2016-11, Vol.106 (6), p.1295-1302

Blithe, Diana L., Ph.D

2016

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Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis

The Lancet (British edition), 2010-02, Vol.375 (9714), p.555-562

2010

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Phase 1 randomized trials to assess safety, pharmacokinetics, and vaginal bleeding associated with use of extended duration dapivirine and levonorgestrel vaginal rings

PloS one, 2024-06, Vol.19 (6), p.e0304552

2024

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The spectrum of endometrial pathology induced by progesterone receptor modulators

Modern pathology, 2008-05, Vol.21 (5), p.591-598

2008

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Effects of a One Year Reusable Contraceptive Vaginal Ring on Vaginal Microflora and the Risk of Vaginal Infection: An Open-Label Prospective Evaluation

PloS one, 2015-08, Vol.10 (8), p.e0134460-e0134460

2015

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Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17

Pharmaceutics, 2024-08, Vol.16 (8), p.1032

2024

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Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials

The Lancet global health, 2019-08, Vol.7 (8), p.e1054-e1064

2019

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Update on Novel Hormonal and Nonhormonal Male Contraceptive Development

The journal of clinical endocrinology and metabolism, 2021-06, Vol.106 (6), p.e2381-e2392

2021

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Participant experiences with a multipurpose vaginal ring for HIV and pregnancy prevention during a phase 1 clinical trial: learning from users to improve acceptability

Frontiers in reproductive health, 2023-07, Vol.5, p.1147628-1147628

2023

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Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods

Clinical chemistry (Baltimore, Md.), 2019-01, Vol.65 (1), p.153-160

2019

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Continuation rates of two different-sized copper intrauterine devices among nulliparous women: Interim 12-month results of a single-blind, randomised, multicentre trial

EClinicalMedicine, 2022-09, Vol.51, p.101554-101554, Article 101554

2022

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Male contraception development: monitoring effective spermatogenesis suppression utilizing a user-controlled sperm concentration test compared with standard semen analysis

Fertility and sterility, 2023-02, Vol.119 (2), p.208-217

2023

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Contraceptive efficacy: Determining the threshold for effective suppression based on sperm concentration, motility, and morphology

Andrology (Oxford), 2024-07, Vol.12 (7), p.1574-1584

2024

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Use of serum evaluation of contraceptive and ovarian hormones to assess reduced risk of pregnancy among women presenting for emergency contraception in a multicenter clinical trial

Contraception (Stoneham), 2024-09, Vol.137, p.110475, Article 110475

2024

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Emergency contraception for individuals weighing 80 kg or greater: A randomized trial of 30 mg ulipristal acetate and 1.5 mg or 3.0 mg levonorgestrel

Contraception (Stoneham), 2024-09, Vol.137, p.110474, Article 110474

2024

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Effects of combined oral contraceptives, depot medroxyprogesterone acetate and the levonorgestrel-releasing intrauterine system on the vaginal microbiome

Contraception (Stoneham), 2017-04, Vol.95 (4), p.405-413

2017

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Menstrual cup use and intrauterine device expulsion in a copper intrauterine device randomized trial

Contraception (Stoneham), 2024-06, Vol.134, p.110415, Article 110415

2024

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Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver

Drug metabolism and disposition, 2022-12, Vol.50 (12), p.1493-1500

2022

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Development of new hormonal male contraception for the couple

Andrology (Oxford), 2024-05, Vol.12 (7), p.1506-1511

2024

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Design of an international male contraceptive efficacy trial using a self-administered daily transdermal gel containing testosterone and segesterone acetate (Nestorone)

Contraception (Stoneham), 2023-08, Vol.124, p.110064-110064, Article 110064

2023

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Daily Oral Administration of the Novel Androgen 11β-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men

The journal of clinical endocrinology and metabolism, 2020-03, Vol.105 (3), p.e835-e847

2020

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Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11β-Methyl-19-Nortestosterone-17β-Dodecylcarbonate in Men

The journal of clinical endocrinology and metabolism, 2019-03, Vol.104 (3), p.629-638

2019

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Poor and variable oral bioavailability of dimethandrolone (DMA), an investigational male hormonal contraceptive, is likely associated with UGT2B17 mediated first‐pass metabolism

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Evaluation of ovulation and safety outcomes in a multi-center randomized trial of three 84 day ulipristal acetate regimens

Contraception (Stoneham), 2022-08, Vol.112, p.54-60

2022

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Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

Biology of reproduction, 2023-12, Vol.109 (6), p.851-863

2023

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Pipeline for contraceptive development

Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis

Phase 1 randomized trials to assess safety, pharmacokinetics, and vaginal bleeding associated with use of extended duration dapivirine and levonorgestrel vaginal rings

The spectrum of endometrial pathology induced by progesterone receptor modulators

Effects of a One Year Reusable Contraceptive Vaginal Ring on Vaginal Microflora and the Risk of Vaginal Infection: An Open-Label Prospective Evaluation

Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17

Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials

Update on Novel Hormonal and Nonhormonal Male Contraceptive Development

Participant experiences with a multipurpose vaginal ring for HIV and pregnancy prevention during a phase 1 clinical trial: learning from users to improve acceptability

Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods

Continuation rates of two different-sized copper intrauterine devices among nulliparous women: Interim 12-month results of a single-blind, randomised, multicentre trial

Male contraception development: monitoring effective spermatogenesis suppression utilizing a user-controlled sperm concentration test compared with standard semen analysis

Contraceptive efficacy: Determining the threshold for effective suppression based on sperm concentration, motility, and morphology

Use of serum evaluation of contraceptive and ovarian hormones to assess reduced risk of pregnancy among women presenting for emergency contraception in a multicenter clinical trial

Emergency contraception for individuals weighing 80 kg or greater: A randomized trial of 30 mg ulipristal acetate and 1.5 mg or 3.0 mg levonorgestrel

Effects of combined oral contraceptives, depot medroxyprogesterone acetate and the levonorgestrel-releasing intrauterine system on the vaginal microbiome

Menstrual cup use and intrauterine device expulsion in a copper intrauterine device randomized trial

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver

Development of new hormonal male contraception for the couple

Design of an international male contraceptive efficacy trial using a self-administered daily transdermal gel containing testosterone and segesterone acetate (Nestorone)

Daily Oral Administration of the Novel Androgen 11β-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men

Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11β-Methyl-19-Nortestosterone-17β-Dodecylcarbonate in Men

Poor and variable oral bioavailability of dimethandrolone (DMA), an investigational male hormonal contraceptive, is likely associated with UGT2B17 mediated first‐pass metabolism

Evaluation of ovulation and safety outcomes in a multi-center randomized trial of three 84 day ulipristal acetate regimens

Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

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