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Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.857-861

2016

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (14), p.3274-3277

2016

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Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands

Bioorganic & medicinal chemistry, 2003-01, Vol.11 (2), p.197-205

2003

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GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6463-6466

2013

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Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

ACS medicinal chemistry letters, 2011-02, Vol.2 (2), p.148-153

2011

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GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6459-6462

2013

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Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4354-4358

2000

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Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4200-4203

2005

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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.358-378

1998

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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386

2002

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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.346-357

1998

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (14)

2016

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Metal Ion-Catalyzed Hydrolysis of Acrylate Esters and Amides by Way of Their Conjugate Addition Adducts

Journal of organic chemistry, 1995-11, Vol.60 (22), p.7238-7246

1995

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[ 3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1919-1922

1998

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Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists

Bioorganic & medicinal chemistry letters, 1997-05, Vol.7 (9), p.1161-1166

1997

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Initial Movements of Re- introduced Elk in the Missouri Ozarks

The American midland naturalist, 2017-07, Vol.178 (1), p.1-16

2017

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Schwere Metformin-assoziierte Laktatazidose

Forum médical suisse (En ligne), 2012-12, Vol.12 (50)

2012

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Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2219-2231

1996

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Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2232-2244

1996

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Delivering GIScience Education via Blended Learning: The GITTA Experience

Teaching Geographic Information Science and Technology in Higher Education, 2011, p.405-420

2011

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Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design

Metal Ion-Catalyzed Hydrolysis of Acrylate Esters and Amides by Way of Their Conjugate Addition Adducts

[ 3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptors

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain : 2005 American Chemical Society Award for Computers in Chemical and Pharmaceutical Research

Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists

Ethyl (3S, 4aR, 6S, 8aR)-6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroisoquinoline-3-c arboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

Initial Movements of Re- introduced Elk in the Missouri Ozarks

Schwere Metformin-assoziierte Laktatazidose

Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution

Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

Delivering GIScience Education via Blended Learning: The GITTA Experience

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