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Experience With 2-Chlorodeoxyadenosine in Previously Untreated Children With Newly Diagnosed Acute Myeloid Leukemia and Myelodysplastic Diseases

Journal of clinical oncology, 2001-06, Vol.19 (11), p.2804-2811

2001

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Lack of correlation between cigarette mainstream smoke particulate phase radicals and hydroquinone yield

Food and chemical toxicology, 2001-04, Vol.39 (4), p.401-406

2001

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2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia

Journal of clinical oncology, 1992-03, Vol.10 (3), p.364-370

1992

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Sensitization of Hematopoietic Stem and Progenitor Cells to Trimetrexate Using Nucleoside Transport Inhibitors

Blood, 1997-11, Vol.90 (9), p.3546-3554

1997

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A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia

Journal of clinical oncology, 1991-03, Vol.9 (3), p.416-422

1991

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A Gene Transfer Strategy for Making Bone Marrow Cells Resistant to Trimetrexate

Blood, 1996-03, Vol.87 (6), p.2579-2587

1996

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Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions

The Journal of biological chemistry, 1994-04, Vol.269 (13), p.9547-9555

1994

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In vivo selection of retrovirally transduced hematopoietic stem cells

Nature medicine, 1998-10, Vol.4 (10), p.1136-1143

1998

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Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3

Biochemical pharmacology, 2000-08, Vol.60 (3), p.325-338

2000

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Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells

Cancer research (Chicago, Ill.), 1989-12, Vol.49 (24), p.6923-6928

1989

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Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1988-07, Vol.263 (21), p.10304-10313

1988

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Mutations in the gene for human dihydrofolate reductase : an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate

Leukemia, 1996-03, Vol.10 (3), p.439-446

1996

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Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia

Blood, 1994-08, Vol.84 (4), p.1237-1242

1994

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Incorporation of 2-halogeno-2'-deoxyadenosine 5-triphosphates into DNA during replication by human polymerases alpha and beta

The Journal of biological chemistry, 1990-03, Vol.265 (7), p.4033-4040

1990

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Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli

The Journal of biological chemistry, 1988-07, Vol.263 (19), p.9187-9198

1988

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Pharmacokinetics of cladribine (2-chlorodeoxyadenosine) in children with acute leukemia

Cancer research (Chicago, Ill.), 1994-03, Vol.54 (5), p.1235-1239

1994

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Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants

Human gene therapy, 1997-11, Vol.8 (17), p.2069-2077

1997

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Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1990-02, Vol.265 (5), p.2740-2748

1990

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Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH

The Journal of biological chemistry, 1990-04, Vol.265 (10), p.5579-5584

1990

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Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor

Cancer research (Chicago, Ill.), 1991-12, Vol.51 (24), p.6568-6573

1991

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Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

The Journal of biological chemistry, 1989-06, Vol.264 (16), p.9391-9399

1989

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Dihydrofolate Reductase from the Pathogenic Fungus Pneumocystis carinii: Catalytic Properties and Interaction with Antifolates

Archives of biochemistry and biophysics, 1993-09, Vol.305 (2), p.499-508

1993

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Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523

Biochemistry (Easton), 1997-11, Vol.36 (45), p.13897-13903

1997

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Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice

Cancer research (Chicago, Ill.), 1989-09, Vol.49 (18), p.4972-4978

1989

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Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers

The Journal of biological chemistry, 1995-03, Vol.270 (10), p.5057-5064

1995

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Experience With 2-Chlorodeoxyadenosine in Previously Untreated Children With Newly Diagnosed Acute Myeloid Leukemia and Myelodysplastic Diseases

Lack of correlation between cigarette mainstream smoke particulate phase radicals and hydroquinone yield

2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia

Sensitization of Hematopoietic Stem and Progenitor Cells to Trimetrexate Using Nucleoside Transport Inhibitors

A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia

A Gene Transfer Strategy for Making Bone Marrow Cells Resistant to Trimetrexate

Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions

In vivo selection of retrovirally transduced hematopoietic stem cells

Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3

Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells

Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

Mutations in the gene for human dihydrofolate reductase : an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate

Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia

Incorporation of 2-halogeno-2'-deoxyadenosine 5-triphosphates into DNA during replication by human polymerases alpha and beta

Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli

Pharmacokinetics of cladribine (2-chlorodeoxyadenosine) in children with acute leukemia

Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants

Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH

Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor

Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

Dihydrofolate Reductase from the Pathogenic Fungus Pneumocystis carinii: Catalytic Properties and Interaction with Antifolates

Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523

Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice

Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers

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